Inhibitory effects of methoxyflavonoid on DNA damage induced by catechol estrogen

饮食中的甲氧基黄酮类化合物金莲花酚可抑制致癌雌激素代谢产物4-OHE2引起的DNA损伤。在分子对接分析中，由于该甲氧基黄酮类化合物的甲氧基之间的空间碰撞，金莲花酚与细胞色素P1B1的活性部位很好地吻合，但与细胞色素P1A2和1A1的活性部位不匹配。这表明这种甲氧基黄酮类化合物可能是一种化学预防调节剂，参与了癌症的发生，如乳腺癌。

A dietary methoxyflavonoid, chrysoeriol, inhibited DNA damage induced by the carcinogenic endogenous estrogen metabolite, 4-OHE2.In a molecular docking analysis, chrysoeriol was found to fit well into the active site of CYP1B1, but not into the active site of CYP1A2 and 1A1 because of steric collisions between the methoxy substituent of this methoxyflavonoid. This indicates that such methoxyflavonoids may be a chemopreventive modulator involved in carcinogenesis such as in breast cancer.