The regulation of separase-securin in the maintenance of chromosomal stability, and its abnormality in cancer development

我发现分离酶（一种被securin抑制的蛋白酶）的自裂解对分离酶活性的适当调节和染色体的及时分离至关重要。我还证明了染色体稳定性的干扰在securin过表达诱导的细胞转化中起作用。这些数据证明了分离-安全蛋白的稳定染色体分离功能与肿瘤发生之间的关系。

I found that auto-cleavage of separase, a protease that is inhibited by securin, is crucial for the proper regulation of separase activity, and the timely chromosome segregation. I also showed that a disturbance of the chromosome stability plays a role in the cell transformation induced by over-expression of securin. These data demonstrate the relationship between the function of separase-securin for the stable chromosome segregation and the tumor development.