Development of research with liposomes toward clinical application for cancer and AIDS

我们制备了一种杂化脂质体（HL），它可以通过在缓冲溶液中对囊泡和胶束分子进行超声处理来制备。我们研究了HL的抗癌和抗艾滋病作用，得到了以下结果。(A)在体外实验中，HL对多种肿瘤细胞的生长均有明显的抑制作用。(B)观察到靶向肿瘤细胞膜的凋亡诱导通路。(C)在体内用HL治疗肝癌小鼠模型获得明显的化疗效果。采用小鼠肿瘤模型进行药代动力学试验，观察荧光标记的HL-25在肿瘤中的长期选择性积累。(D)获得与艾滋病相关的淋巴瘤的治疗效果。这些发现提示，HL可能是一种靶向难治性疾病细胞膜，引发各种癌细胞凋亡的新型抗癌抗艾滋病纳米药物。

We have produced hybrid liposomes (HL) which can be prepared by sonication of vesicular and micellar molecules in a buffer solution. We investigated the anticancer and anti-AIDS effects of HL and following results are obtained. (A) The remarkable inhibitory effects of HL on the growth of various tumor cells were attained in vitro. (B) apoptotic induction pathway which targeted tumor cell membranes was observed. (C) Significantly chemotherapeutic effects were obtained using mice model of carcinoma after the treatment with HL in vivo. Long-term selective accumulation of fluorescent labeled HL-25 into tumor was observed in pharmacokinetics test using mice model of carcinoma. (D) therapetutic effects of treatment for the lymphoma with relation to AIDS was obtained. These findings suggest that HL should be a new type of nanomedicinaldrug anti-cancer and anti-AIDS that targets refractory disease cell-membranes to trigger apoptotic cell death for various cancer cells.