Development of research with liposomes toward clinical application for cancer and AIDS

脂质体在癌症和艾滋病临床应用方面的研究进展

• 批准号: 23300173
• 负责人: MATSUMOTO Yoko
• 金额: $ 11.48万
• 依托单位: Sojo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23300173/
• 关键词: 癌; リポソーム; エイズ; アポトーシス; 担がんマウス; トレハロース; シグナル伝達; トランスレーショナルリサーチ; 脂質; 細胞・組織

We have produced hybrid liposomes (HL) which can be prepared by sonication of vesicular and micellar molecules in a buffer solution. We investigated the anticancer and anti-AIDS effects of HL and following results are obtained. (A) The remarkable inhibitory effects of HL on the growth of various tumor cells were attained in vitro. (B) apoptotic induction pathway which targeted tumor cell membranes was observed. (C) Significantly chemotherapeutic effects were obtained using mice model of carcinoma after the treatment with HL in vivo. Long-term selective accumulation of fluorescent labeled HL-25 into tumor was observed in pharmacokinetics test using mice model of carcinoma. (D) therapetutic effects of treatment for the lymphoma with relation to AIDS was obtained. These findings suggest that HL should be a new type of nanomedicinaldrug anti-cancer and anti-AIDS that targets refractory disease cell-membranes to trigger apoptotic cell death for various cancer cells.

我们生产了混合脂质体 (HL)，它可以通过在缓冲溶液中超声处理囊泡和胶束分子来制备。我们研究了 HL 的抗癌和抗艾滋病作用，得到了以下结果。 (A) HL在体外对多种肿瘤细胞的生长具有显着的抑制作用。 (B)观察到针对肿瘤细胞膜的凋亡诱导途径。 (C) 使用HL体内治疗后的小鼠癌症模型获得了显着的化疗效果。在小鼠癌症模型的药代动力学测试中观察到荧光标记的HL-25在肿瘤中长期选择性积累。 (D)获得与艾滋病相关的淋巴瘤的治疗效果。这些发现表明，HL应该是一种新型的抗癌和抗艾滋病纳米药物，它靶向难治性疾病细胞膜，引发各种癌细胞的凋亡细胞死亡。

项目成果

Anti-tumor effects of Cationic hybrid liposomes Against colon carcinoma along with apoptosis

阳离子杂化脂质体抗结肠癌及细胞凋亡的抗肿瘤作用

• 发表时间: 2012
• 作者: 亀井 謙一郎;劉 莉;吉岡 桃子;長谷川 光一;中辻 憲夫;陳 勇;日野 元貴
• 通讯作者: 日野 元貴

New Cancer Immunotherapy Using Autologous Lymphocytes Activated with Trastuzumab

• DOI: 10.1248/bpb.b12-00378
• 发表时间: 2012-08-01
• 期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN
• 影响因子: 2
• 作者: Nakagawa, Shinichirou;Matsuoka, Yusuke;Ueoka, Ryuichi
• 通讯作者: Ueoka, Ryuichi

Cell cycle arrest by adding hybrid liposomes for lung tumor

通过添加混合脂质体来抑制肺肿瘤的细胞周期

• 发表时间: 2013
• 作者: Yoko Matsumoto;Yuji Komizu;Mamiko Yukihara; Ryuichi Ueoka
• 通讯作者: Ryuichi Ueoka

Inhibitory Effects of Hybrid Liposomes on the Growth of Synoviocyte Causing Rheumatoid Arthritis

混合脂质体对类风湿性关节炎滑膜细胞生长的抑制作用

• 发表时间: 2011
• 期刊: Bioorganic & Medicinal Chemistry Letters
• 影响因子: 2.7
• 作者: 濱田勉;岸本祐子;高木昌宏;海埜孝夫;Hideaki Ichihara
• 通讯作者: Hideaki Ichihara

Experimental Therapeutic Effects of Hybrid Liposomes on the Alzheimer's Disease in Vitro

混合脂质体对阿尔茨海默病的体外实验治疗效果

• DOI: 10.1248/yakushi.131.775
• 发表时间: 2011
• 期刊: YAKUGAKU ZASSHI
• 影响因子: 0.3
• 作者: Y. Nishiyama;K. Hatanaka;座古恵子
• 通讯作者: 座古恵子