Creation of intelligent nanocarrier by effector-function elaboration to polymer materials

点击翻译按钮获取中文摘要

The functional elaborations including stability in serum medium, cellular uptake, cellular distribution and transcription / translation process are important in the development of the gene vector. Many studies have been performed for these subjects, but there are only a few reports on the promotion of efficiency of a transcription process yet. In this study, we developed the polymeric materials that could exhibit effective a transcription / the translation efficiency and also clarify the mechanism for these materials. Furthermore, we achieved the effective gene expression through the combination of the developed polymeric materials with cationic lipids.