Developments of high performance ferromagnetic nanoparticles and a dynamic hysteresis loop measurement system for magnetic hyperthermia

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For the purpose of realization of the hyperthermia cancer treatment killing by using an alternating magnetic field from the outside of human bodies without surgical operations, ferromagnetic nanoparticles as a heating element and the system for performance evaluation under an wide range AC magnetic field. were developed.As magnetic nanoparticles with fair biocompatibility allowing a high heat generation, the elliptical plate Fe oxide nanoparticles were focused on. The dispersibility was improved and particle sizes of nanoparticles were controlled. The heating power of 600W/g and 1700 W/g were obtained under the AC magnetic field at [110kHz, 640 Oe] and [450 kHz, 500 Oe], respectively. Magnetic field generator and dynamic hysteresis measurement system were developed, making it possible to measure the behavior of the dynamic magnetization at the heating state. This enables us to discuss the complex mechanisms of nanoparticle heating exothermic and gives a guideline for material design.