Analysis of tumor-rejecting biological reactions induced by tumor specific immune responses

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This study was aiming to reveal the immune responses induced in tumor mass and tumor-rejecting biological responses induced by specific anti-tumor immune responses. I have reported that (1) Critical roles of IFN-gamma produced by primarily infiltrating NK cells for entire anti-tumor immune responses (2) Immune suppression by MHC Class II-dressed NK cells (3) novel therapy basing on the specific phenotypic changes of tumor infiltrating CTLs. I am now going to prepare the reports concerning the mechanisms that immune responses induce resistance against anti-tumor immune responses in targeted-tumor cells and the biological responses specifically induced in the rejected tumor mass.