A living body action and the application to medical treatment by inhalation of atmospheric pressure plasma flow

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We carried out the experiments about the direct inhalationto animal model (pulmonary hypertension of goat or mini-pig and neonatal hypoxia/ischemia rat). The use of inhalated plasma, generated by the atmospheric-pressure plasmas reactor, resulted in increased saturation pulse oxygen in the pulmonary hypertension of animals. Additionally, the blood pressure decreased during plasma inhalation. Nitric oxide (NO) concentrations in the arteries increased after 20 seconds of plasma inhalation, reaching a maximum value at about 160 s and gradually decreased. The NO generated by this device was highly concentrated, reaching a maximum of approximately 10nmol. Moreover, the infarct areas treated with plasma inhalation (15days, 90sec inhalation/ day) were evaluated in the neonatal hypoxic/ischemic rat model. Each plasma inhalation-treated group (n=6) demonstrated significant increae of new bood vessels compared with the no treated group (n=6).