A living body action and the application to medical treatment by inhalation of atmospheric pressure plasma flow

我们进行了直接吸入动物模型（山羊或迷你猪肺动脉高压和新生儿缺氧/缺血大鼠）的实验。使用由大气压等离子体反应器产生的吸入等离子体，导致肺动脉高压动物的饱和脉冲氧增加。此外，吸入血浆时血压降低。动脉内一氧化氮（NO）浓度在吸入血浆20秒后升高，在160秒左右达到最大值，随后逐渐降低。该装置生成的NO浓度很高，最高可达约10nmol。此外，在新生儿缺氧/缺血大鼠模型中，对血浆吸入治疗（15天，吸入90秒/天）的梗死区域进行评估。各血浆吸入治疗组（n=6）与未治疗组（n=6）相比，新生血管明显增加。

We carried out the experiments about the direct inhalationto animal model (pulmonary hypertension of goat or mini-pig and neonatal hypoxia/ischemia rat). The use of inhalated plasma, generated by the atmospheric-pressure plasmas reactor, resulted in increased saturation pulse oxygen in the pulmonary hypertension of animals. Additionally, the blood pressure decreased during plasma inhalation. Nitric oxide (NO) concentrations in the arteries increased after 20 seconds of plasma inhalation, reaching a maximum value at about 160 s and gradually decreased. The NO generated by this device was highly concentrated, reaching a maximum of approximately 10nmol. Moreover, the infarct areas treated with plasma inhalation (15days, 90sec inhalation/ day) were evaluated in the neonatal hypoxic/ischemic rat model. Each plasma inhalation-treated group (n=6) demonstrated significant increae of new bood vessels compared with the no treated group (n=6).