A living body action and the application to medical treatment by inhalation of atmospheric pressure plasma flow

吸入常压等离子流的生物体作用及其在医疗中的应用

• 批准号: 23340180
• 负责人: MORI Akira
• 金额: $ 3.49万
• 依托单位: Tokyo City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23340180/
• 关键词: プラズマ吸入; ﾌﾟﾗｽﾞﾏ医学; 重症呼吸障害; 低酸素性虚血性脳症; 再生医療; プラズマ医学

We carried out the experiments about the direct inhalationto animal model (pulmonary hypertension of goat or mini-pig and neonatal hypoxia/ischemia rat). The use of inhalated plasma, generated by the atmospheric-pressure plasmas reactor, resulted in increased saturation pulse oxygen in the pulmonary hypertension of animals. Additionally, the blood pressure decreased during plasma inhalation. Nitric oxide (NO) concentrations in the arteries increased after 20 seconds of plasma inhalation, reaching a maximum value at about 160 s and gradually decreased. The NO generated by this device was highly concentrated, reaching a maximum of approximately 10nmol. Moreover, the infarct areas treated with plasma inhalation (15days, 90sec inhalation/ day) were evaluated in the neonatal hypoxic/ischemic rat model. Each plasma inhalation-treated group (n=6) demonstrated significant increae of new bood vessels compared with the no treated group (n=6).

本实验采用动物模型（山羊肺动脉高压、小型猪肺动脉高压和新生大鼠缺氧/缺血）进行直接吸入实验。使用大气压等离子体反应器产生的吸入等离子体，导致动物肺动脉高压的饱和脉搏氧增加。此外，血浆吸入期间血压降低。吸入血浆20秒后，动脉中一氧化氮（NO）浓度升高，在约160秒时达到最大值，然后逐渐下降。由该装置产生的NO高度浓缩，达到约10 nmol的最大值。此外，在新生缺氧/缺血大鼠模型中评价了用血浆吸入（15天，90秒吸入/天）治疗的梗塞面积。与未治疗组（n = 6）相比，各血浆吸入治疗组（n =6）的新生血管数均显著增加。

项目成果

The Effect of Plasma Inhalation for the Cardiovascular System by Rat

血浆吸入对大鼠心血管系统的影响

• DOI: 10.14243/jsaem.21.260
• 发表时间: 2013
• 期刊: Journal of the Japan Society of Applied Electromagnetics and Mechanics
• 作者: Shigeru MURATA;Akira MORI;Masaya WATADA;Takamichi HIRATA;Chihiro TSUTSUI;Akane KONDO;Genu TAKAHASHI
• 通讯作者: Genu TAKAHASHI

Treatment of Cardiac Disease by Inhalation of Atmospheric Pressure Plasma Flow

吸入常压血浆流治疗心脏病

• 发表时间: 2014
• 期刊: Japanese Journal of Applied Physics
• 影响因子: 1.5
• 作者: T. Hirata;Takumi Kishimoto;Chihiro Tsutsui;Takao Kanai;Akira Mori
• 通讯作者: Akira Mori

マイクロスポットプラズマ源による血管新生促進メカニズム

微点等离子体源促进血管生成的机制

• 发表时间: 2011
• 作者: 筒井千尋;平田孝道;横井由貴子;小町俊文;岸本巧巳;村田茂;森晃;秋谷昌宏;山本俊昭;田口亮
• 通讯作者: 田口亮

Healing Burns Using Atmospheric Pressure Plasma Irradiation

使用大气压等离子体照射治愈烧伤

• 发表时间: 2013
• 期刊: Japanese Journal of Applied Physics
• 影响因子: 1.5
• 作者: T. Hirata;Takumi Kishimoto;Chihiro Tsutsui;Takao Kanai;Akira Mori
• 通讯作者: Akira Mori

Uteroplacental circulation and maternal abdominal aortic stiffness in normal and compromised pregnancy : its therapy by the atmospheric pressure plasma

正常妊娠和受损妊娠中的子宫胎盘循环和母体腹主动脉僵硬度：常压等离子体的治疗

• 发表时间: 2012
• 作者: A. Mori;S. Murata;T. Hirata;Y. Kudo;M. Iwashita
• 通讯作者: M. Iwashita