Elucidation of the chemical processes of biological reactions based on the design of novel nano-sized reaction environments

具有树状大分子骨架的新型纳米分子腔被开发出来，用于模拟酶活性部位的反应环境，使高活性中间体能够稳定。利用新的模型化合物，成功地合成了几个在人工体系中非常不稳定的高活性物种，并阐明了它们的反应活性。这些结果有助于对参与氧化还原调节和信号转导的假想化学过程进行实验论证。

Novel nano-sized molecular cavities with a dendrimer-type framework were developed for modeling reaction environments in the active site of enzymes that enable the stabilization highly reactive intermediates. By utilizing the novel model compounds, several highly reactive species otherwise very unstable in artificial systems were successfully synthesized and their reactivities were elucidated. These results contribute to the experimental demonstration of the hypothetically proposed chemical processes involved in the redox regulation and signaling.