Elucidation of the chemical processes of biological reactions based on the design of novel nano-sized reaction environments

开发了具有树突型框架的新型纳米分子腔，用于模拟酶活性位点的反应环境，从而稳定高活性中间体。利用新型模型化合物，成功合成了几种在人工体系中极不稳定的高活性物质，并对其反应活性进行了分析。这些结果有助于实验证明假设提出的化学过程涉及氧化还原调节和信号传导。

Novel nano-sized molecular cavities with a dendrimer-type framework were developed for modeling reaction environments in the active site of enzymes that enable the stabilization highly reactive intermediates. By utilizing the novel model compounds, several highly reactive species otherwise very unstable in artificial systems were successfully synthesized and their reactivities were elucidated. These results contribute to the experimental demonstration of the hypothetically proposed chemical processes involved in the redox regulation and signaling.