Elucidation of the chemical processes of biological reactions based on the design of novel nano-sized reaction environments

新型纳米尺寸的分子腔与树枝状聚合物型的框架被开发用于模拟反应环境中的活性位点的酶，使稳定的高活性中间体。 利用这些新的模型化合物，成功地合成了几种在人工体系中非常不稳定的高活性物种，并阐明了它们的反应活性。 这些结果有助于实验演示的假设提出的化学过程中涉及的氧化还原调节和信号。

Novel nano-sized molecular cavities with a dendrimer-type framework were developed for modeling reaction environments in the active site of enzymes that enable the stabilization highly reactive intermediates. By utilizing the novel model compounds, several highly reactive species otherwise very unstable in artificial systems were successfully synthesized and their reactivities were elucidated. These results contribute to the experimental demonstration of the hypothetically proposed chemical processes involved in the redox regulation and signaling.