Enhancement of local electric field in the atto-liter space and its application for ultra sensitive screening tips

本研究的目标是在亚波长以下的空间中构建一个可控的阿托升空间，并将等离子体共振场限制在该空间中，以实现超高灵敏度的生物传感。然后，我们得到了一个独特的结构制作方法模板聚苯乙烯球形颗粒和适当的条件下，结构复制通过纳米压印工艺，也证明了局部表面等离子体芯片显示超高的灵敏度，即使样品中含有一定的污染物。此外，我们开发了一个原型测试系统，包括掌上型光学测量仪器和远程操作终端，这是不包括在本项目的原始计划，并成功地阐明了一个实际的图像的真实的应用。该研究成果将导致实现生物筛查测试和即时检测，具有无标记，简单和超高灵敏度的特点。

In this research, it have aimed to fabricate a controlled atto-liter space whose dimension below a sub-wavelength and to confine a plasmon resonance field into the space in order to achieve ultrahigh-sensitive biosensing. Then, we obtained a unique structure fabrication method templating polystylene spherical particles and an appropriate condition for structure replication via nanoimprinting process, and also proved that the local surface plasmon chip exhibits ultra-high sensitivity even for the sample containing a certain contaminant. Moreover, we have developed a prototype testing system consists of palmtop optical measurement apparatus and remote operation terminal that was not included in the original plan of this project, and succeeded to clarify a practical image of the real application. The outcome of the research will lead to the realization of bio-screening testing and point-of-care testing with a feature of label-free, simple, and ultra-high sensitivity.