Development of environment benign synthetic process based on the enzymatic reaction using solid acid or base as a cooperative catalysis

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Investigation for developing the efficient process of dynamic kinetic resolution (DKR) of secondary alcohols has been conducted: the desired DKR reaction has been accomplished through the combination of lipase-catalyzed enantioselective transesterification and zeolite-mediated racemization of the substrates. Among zeolites evaluated, H-beta-VALFOR CP8111BL-25 was the best racemization catalyst and a mixed solvent system, hexane with ionic liquid was the suitable solvent system. Zeolite mediated racemization significantly depend on the ionic liquids, racemization proceeded smoothly in imidazolium or quaternary ammonium, while no racemization took place in phosphonium salts ionic liquids. It has also been established that a combination of ionic liquid coated lipase PS (IL1-PS) and H-beta-VALFOR CP8111BL-25 in diisopropyl ether solvent system afforded good results and achieved efficient DKR system of aryl alcohols.