Development of environment benign synthetic process based on the enzymatic reaction using solid acid or base as a cooperative catalysis

探索了一种高效的仲醇动态动力学拆分(DKR)方法：通过脂肪酶催化的对映选择性酯交换反应和分子筛催化的底物外消旋反应，获得了理想的DKR反应。在所评价的分子筛中，H-β-VALFOR CP8111BL-25是最好的外消旋催化剂和混合溶剂体系，正己烷和离子液体是合适的溶剂体系。分子筛对离子液体有很强的依赖性，在咪唑类或季铵盐类离子液体中消旋反应顺利进行，而在膦盐类离子液体中不发生消旋反应。离子液体包被脂肪酶PS(IL1-PS)与H-β-VALFOR CP8111BL-25在二异丙醚溶剂体系中的结合效果较好，得到了高效的芳香醇DKR体系。

Investigation for developing the efficient process of dynamic kinetic resolution (DKR) of secondary alcohols has been conducted: the desired DKR reaction has been accomplished through the combination of lipase-catalyzed enantioselective transesterification and zeolite-mediated racemization of the substrates. Among zeolites evaluated, H-beta-VALFOR CP8111BL-25 was the best racemization catalyst and a mixed solvent system, hexane with ionic liquid was the suitable solvent system. Zeolite mediated racemization significantly depend on the ionic liquids, racemization proceeded smoothly in imidazolium or quaternary ammonium, while no racemization took place in phosphonium salts ionic liquids. It has also been established that a combination of ionic liquid coated lipase PS (IL1-PS) and H-beta-VALFOR CP8111BL-25 in diisopropyl ether solvent system afforded good results and achieved efficient DKR system of aryl alcohols.