Development of medicinal molecules having biologically functions targeting the PI3K/Akt pathway and the TGF-b/Smad pathway

本研究旨在设计和合成PI3K/Akt通路的激活剂和TGF-b/Smad通路的抑制剂，开发调节这两种通路串扰的药物。针对PI3K/Akt通路，合成了包含磷酸肌醇和二酰基甘油部分的化合物。以TGF-b/Smad通路为靶点，合成了含有吡啶和金属结合侧链的化合物。这些化合物可以作为脑保护剂、糖尿病、癌症、癌症转移和硬皮病的药物。

The present study aimed at the design and synthesis of activators of the PI3K/Akt pathway and inhibitors of the TGF-b/Smad pathway to develop drugs to regulate the crosstalk of the two pathways. Targeting the PI3K/Akt pathway, compounds comprising inositol phosphate and diacyl glycerol moiety were synthesized. Targeting the TGF-b/Smad pathway, compounds comprising the pyridine and metal-binding side chains were synthesized. These compounds could be useful as brain-protecting agents, drugs for diabetes, cancer, cancer metastasis, and scleroderma.