Adjuvant effect of chemicals on contact hypersensitivity through transient receptor potential channels

化学物质在过敏中的辅助作用机制在很大程度上是未知的。我们使用接触性超敏小鼠模型证明了TRPA1通道参与邻苯二甲酸酯的佐剂活性。这一结论得到了TRPA1激动剂天然产物中佐剂活性的存在以及TRPA1拮抗剂实验的支持。TRPA1的活化被发现对预测替代增塑剂的佐剂效果是有用的，这些增塑剂广泛用于化妆品和药物配方。

Adjuvant mechanisms of chemicals in allergy are largely unknown. We demonstrated that TRPA1 channels are involved in the adjuvant activity of phthalate esters using a contact hypersensitivity mouse model. This conclusion was supported by the presence of adjuvant activity in TRPA1 agonistic natural products as well as by experiments using a TRPA1 antagonist. TRPA1 activation was found to be useful for the prediction of adjuvant effect using alternative plasticizers that are widely used for cosmetics and drug formulation.