Adjuvant effect mechanism on contact sensitization through nociceptive receptors

在过敏的发展过程中，化学物质的佐剂活性的重要性已被广泛认识。然而，佐剂活性的机制在很大程度上是未知的。通过小鼠接触超敏性模型，我们发现邻苯二甲酸酯的佐剂活性与激活在感觉神经元上表达的伤害性受体的能力相关。我们还发现邻苯二甲酸酯揭示了具有低免疫原性的食物成分的皮肤致敏活性。

Importance of the adjuvant activity of chemicals has become widely recognized in the development of allergies. However, mechanisms underlying the adjuvant activity are largely unknown. Using mouse contact hypersentitivity models, we discovered that the adjuvant activity of phthalate esters is correlated with the ability to activate nociceptive receptors, which are expressed on sensory neurons. We also found that phthalate esters uncovered the skin-sensitizing activity of a food constituent that has low immunogenicity.