The role of CD169 macrophages in anti-tumor immunity induced by dead tumor cells

CD169巨噬细胞在死亡肿瘤细胞诱导的抗肿瘤免疫中的作用

• 批准号: 23390095
• 负责人: TANAKA Masato
• 金额: $ 12.65万
• 依托单位: Tokyo University of Pharmacy and Life Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390095/
• 关键词: がん; マクロファージ; 細胞死

In this study, we tried to reveal the molecular and cellular mechanisms of activation of anti-tumor immunity by CD169-positive macrophages located in lymph node sinus. We generated CD169-Cre-YFP mice, in which CD169-positive macrophages were specifically labeled with YFP, and examined the character of these cells using the mice. We also identified CD169 macrophages-producing molecules that may be able to activate anti-tumor immunity. We established an experimental model to induce cell death of tumor cells in tumor-bearing mice, found the drastic changes in tumor-associated macrophages after tumor cell death. We also reveal the roles of CD169 macrophages in the immune regulation in non-immune tissues.

在本研究中，我们试图揭示CD169阳性巨噬细胞激活抗肿瘤免疫的分子和细胞机制。我们建立了CD169-Cre-YFP小鼠，在其中CD169阳性的巨噬细胞被YFP特异性标记，并用小鼠检测这些细胞的特性。我们还鉴定了产生CD169巨噬细胞的分子，这些分子可能能够激活抗肿瘤免疫。我们建立了诱导荷瘤小鼠肿瘤细胞死亡的实验模型，发现肿瘤细胞死亡后肿瘤相关巨噬细胞发生了剧烈的变化。我们还揭示了CD169巨噬细胞在非免疫组织中的免疫调节作用。

项目成果

Regulation of anti-tumor immunity by clearance of dead tumor cells

通过清除死亡肿瘤细胞来调节抗肿瘤免疫

• 发表时间: 2011
• 作者: 米澤 傑;山田宗茂;横山勢也;北本 祥;田畑和宏;東美智代;喜夛村次郎;田中正人
• 通讯作者: 田中正人

CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress.

• DOI: 10.1038/nm.3057
• 发表时间: 2013-04
• 期刊: Nature medicine
• 影响因子: 82.9

The role of CD169 macrophages in anti-tumor immunity

CD169巨噬细胞在抗肿瘤免疫中的作用

• 发表时间: 2011
• 作者: Imamura;Ryu;田中正人
• 通讯作者: 田中正人

Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus

• DOI: 10.1038/ni.2169
• 发表时间: 2012-01-01
• 期刊: NATURE IMMUNOLOGY
• 影响因子: 30.5
• 作者: Honke, Nadine;Shaabani, Namir;Lang, Karl S.
• 通讯作者: Lang, Karl S.

CD169-Positive Macrophages Dominate Antitumor Immunity by Crosspresenting Dead Cell-Associated Antigens

• DOI: 10.1016/j.immuni.2010.12.011
• 发表时间: 2011-01-28
• 期刊: IMMUNITY
• 影响因子: 32.4
• 作者: Asano, Kenichi;Nabeyama, Ami;Tanaka, Masato
• 通讯作者: Tanaka, Masato