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The role of CD169 macrophages in anti-tumor immunity induced by dead tumor cells

The role of CD169 macrophages in anti-tumor immunity induced by dead tumor cells
CD169巨噬细胞在死亡肿瘤细胞诱导的抗肿瘤免疫中的作用
批准号:
23390095
负责人:
TANAKA Masato
金额:
$12.65万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31

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中文摘要
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英文摘要
In this study, we tried to reveal the molecular and cellular mechanisms of activation of anti-tumor immunity by CD169-positive macrophages located in lymph node sinus. We generated CD169-Cre-YFP mice, in which CD169-positive macrophages were specifically labeled with YFP, and examined the character of these cells using the mice. We also identified CD169 macrophages-producing molecules that may be able to activate anti-tumor immunity. We established an experimental model to induce cell death of tumor cells in tumor-bearing mice, found the drastic changes in tumor-associated macrophages after tumor cell death. We also reveal the roles of CD169 macrophages in the immune regulation in non-immune tissues.
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会议论文
Regulation of anti-tumor immunity by clearance of dead tumor cells
通过清除死亡肿瘤细胞来调节抗肿瘤免疫
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [米澤 傑, 山田宗茂, 横山勢也, 北本 祥, 田畑和宏, 東美智代, 喜夛村次郎, 田中正人]
通讯作者: 田中正人
DOI: 10.1038/nm.3057
发表时间: 2013-04
期刊: Nature medicine
影响因子: 82.9
作者: []
通讯作者:
The role of CD169 macrophages in anti-tumor immunity
CD169巨噬细胞在抗肿瘤免疫中的作用
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Imamura, Ryu, 田中正人]
通讯作者: 田中正人
DOI: 10.1016/j.immuni.2010.12.011
发表时间: 2011-01-28
期刊: IMMUNITY
影响因子: 32.4
作者: [Asano, Kenichi, Nabeyama, Ami, Tanaka, Masato]
通讯作者: Tanaka, Masato
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