The role of CD169 macrophages in anti-tumor immunity induced by dead tumor cells
The role of CD169 macrophages in anti-tumor immunity induced by dead tumor cells
批准号:
23390095
负责人:
TANAKA Masato
金额:
$12.65万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31
中文摘要
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英文摘要
In this study, we tried to reveal the molecular and cellular mechanisms of activation of anti-tumor immunity by CD169-positive macrophages located in lymph node sinus. We generated CD169-Cre-YFP mice, in which CD169-positive macrophages were specifically labeled with YFP, and examined the character of these cells using the mice. We also identified CD169 macrophages-producing molecules that may be able to activate anti-tumor immunity. We established an experimental model to induce cell death of tumor cells in tumor-bearing mice, found the drastic changes in tumor-associated macrophages after tumor cell death. We also reveal the roles of CD169 macrophages in the immune regulation in non-immune tissues.
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Regulation of anti-tumor immunity by clearance of dead tumor cells
通过清除死亡肿瘤细胞来调节抗肿瘤免疫
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[米澤 傑, 山田宗茂, 横山勢也, 北本 祥, 田畑和宏, 東美智代, 喜夛村次郎, 田中正人]
通讯作者:
田中正人
DOI:
10.1038/nm.3057
发表时间:
2013-04
期刊:
Nature medicine
影响因子:
82.9
作者:
[]
通讯作者:
The role of CD169 macrophages in anti-tumor immunity
CD169巨噬细胞在抗肿瘤免疫中的作用
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Imamura, Ryu, 田中正人]
通讯作者:
田中正人
DOI:
10.1016/j.immuni.2010.12.011
发表时间:
2011-01-28
期刊:
IMMUNITY
影响因子:
32.4
作者:
[Asano, Kenichi, Nabeyama, Ami, Tanaka, Masato]
通讯作者:
Tanaka, Masato
DOI:
10.1038/ni.2169
发表时间:
2012-01-01
期刊:
NATURE IMMUNOLOGY
影响因子:
30.5
作者:
[Honke, Nadine, Shaabani, Namir, Lang, Karl S.]
通讯作者:
Lang, Karl S.
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批准号:17K06736
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.33万
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Neural regeneration in spinal cord injury using combination of photoreactive gelatin and a fusion protein of hepatocyte growth factor
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Research on the relationship between KANSEI information and body movements
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Development of catalytic polysilanylation using hydropolysilanes
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批准号:21605005
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Mechanisms of tolerance induction by apoptotic cell phagocytosis
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Synthesis and Catalytic Properties of Hemi-labile Ligands
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$20.22万
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The roles of kinetic information and sensuous information on motor control
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资助金额:$2.43万
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Physiological roles of apoptotic cell clearance
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批准号:16601004
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:2004
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负责人:TANAKA Masato
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依托单位:
Molecular Mechanisms of Apoptotic Cell Phagocytosis by Macrophages
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批准号:14599006
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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PreParation of Fine Composite Particles with Phase-Inversion-Chemical-Pulverization by use of Expanded Polystyrene
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批准号:14550733
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资助金额:$2.05万
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Molecular mechanism for phagocytosis of apoptotic cells
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批准号:12670115
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资助金额:$2.18万
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Non-contact Measuring System for Surface Wear Dent of Journal Bearing
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依托单位:
Preparation of fine polymer particles coated with electric conductive powder by recycle of expanded polystyrene
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批准号:10650740
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项目类别:Grant-in-Aid for Scientific Research (C)
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财政年份:1998
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依托单位:
A New Theoretical Model and Dynamic Characteristics of Two-Phase Oil Film Flow in Very High Speed Journal Bearing
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批准号:09305014
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$23.42万
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财政年份:1997
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依托单位:
Axial Oil Film Rupture in High Speed Journal Bearings and Its Effect on the Rotordynamic Coefficients.
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批准号:07455070
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资助金额:$5.25万
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财政年份:1995
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依托单位:
DEVELOPMENT OF PRACTICAL COMPUTER-AIDED DESIGN TOOL FOR JOURNAL BEARINGS BASED ON ELASTO-THERMOHYDRODYNAMIC LUBRICATION THEORY AND ITS PROOF TEST
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依托单位:
Preparation of functionally gradient composite polymer particles by suspension polymerization
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批准号:06650855
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依托单位:
RESEARCH OF SQUEEZE FILE DAMPER BEARING FOR ENGINES OF AUTOMOBILES
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批准号:05452141
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负责人:TANAKA Masato
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依托单位:
Development of fast and accurate Software of Dynamic Journal Bearings
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批准号:63850050
-
项目类别:Grant-in-Aid for Developmental Scientific Research
-
资助金额:$3.26万
-
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负责人:TANAKA Masato
-
依托单位:
海外基金