Mechanisms of tolerance induction by apoptotic cell phagocytosis
Mechanisms of tolerance induction by apoptotic cell phagocytosis
批准号:
19390117
负责人:
TANAKA Masato
金额:
$11.81万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
The intravenous injection of apoptotic cells can induce cell associated antigen-specific immunosuppression or tolerance. This mechanism of tolerance induction requires the contributions of two populations of cells in the splenic marginal zone, macrophages that rapidly clear corpse in the blood flow, and CD8・^+, CD103^+ DCs that selectively phagocytose dead cell and subsequently present dead cell-associated antigen.
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Macrophages in the marginal zone regulate selective clearance of dying cells by CD8α dendritic cells and induction of tolerance to cell-associated antigens.
边缘区的巨噬细胞通过 CD8α 树突状细胞调节垂死细胞的选择性清除,并诱导对细胞相关抗原的耐受。
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Miyake, Y.]
通讯作者:
Y.
食細胞による死細胞貪食を介した免疫寛容誘導
通过吞噬细胞吞噬死细胞诱导免疫耐受
DOI:
--
发表时间:
2009
期刊:
医学のあゆみ 230
影响因子:
--
作者:
[三宅靖延, 他]
通讯作者:
他
死細胞貪食による免疫制御機構
吞噬死亡细胞的免疫控制机制
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Chun-Hong Qiu, 他, 盛永直子・八尋錦之助・松浦玄・野田公俊, 田中正人]
通讯作者:
田中正人
DOI:
10.1172/jci31990
发表时间:
2007-08-01
期刊:
JOURNAL OF CLINICAL INVESTIGATION
影响因子:
15.9
作者:
[Miyake, Yasunobu, Asano, Kenichi, Tanaka, Masato]
通讯作者:
Tanaka, Masato
DOI:
10.4049/jimmunol.178.8.5001
发表时间:
2007-04-15
期刊:
JOURNAL OF IMMUNOLOGY
影响因子:
4.4
作者:
[Miyake, Yasunobu, Kaise, Hitomi, Tanaka, Masato]
通讯作者:
Tanaka, Masato
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