Development of new method detecting redox regulation against oxidative stress

开发检测氧化应激氧化还原调节的新方法

• 批准号: 23390152
• 负责人: NAKAMURA Hajime
• 金额: $ 11.98万
• 依托单位: The Tazuke Kofukai
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390152/
• 关键词: チオレドキシン; 急性腎障害; 慢性腎臓病; 酸化ストレス; 血液透析; 末梢血リンパ球; 過酸化水素; バイオマーカー; レドックス; ヒト末梢血リンパ球; mRNA; RT-PCR

Thioredoxin is a redox-regulating protein which is induced by oxidative stress. We previously reported that plasma/serum levels of thioredoxin are elevated in diseases associated with oxidative stress. In this study, we found that urinary levels of thioredoxin are correlated with urinary levels of N-acetyl-beta-D-glucosamidase which is a marker for damage of renal tubules in chronic renal diseases. We have developed a new rapid method detecting the elevation of thioredoxin mRNA. It is possible to diagnose rapidly the pathological condition suffering from oxidative stress.

硫氧还蛋白是氧化应激诱导的氧化还原调节蛋白。我们以前报道过血浆/血清硫氧还蛋白水平在与氧化应激相关的疾病中升高。在这项研究中，我们发现尿硫氧还蛋白水平与尿N-乙酰-β-D-氨基葡萄糖苷酶水平相关，后者是慢性肾脏疾病中肾小管损伤的标志物。我们建立了一种新的快速检测硫氧还蛋白mRNA水平的方法。这是可能的，以快速诊断的病理条件遭受氧化应激。

项目成果

Yeast thioredoxin-enriched extracts for mitigating the allergenicity of foods

富含硫氧还蛋白的酵母提取物可减轻食物的过敏性

• 发表时间: 2011
• 期刊: Biosci. Biotechnol. Biochem
• 作者: Taketani Y;Kinugasa K;Furukawa S;Nakamura H;Otsuki R;Yasuda H;Fujita T;Kanzaki K;Masutani H;Yodoi J
• 通讯作者: Yodoi J

当院の造影CT 検査における検査説明・チェック表・同意書の運用について

关于本院增强CT检查的检查说明、检查表、同意书的使用

• 发表时间: 2013
• 作者: 伊藤寿夫;中村肇;奥村亮介;濱野孝志;下村弘一;今阪剛;渡壁一雄;奥井詩帆;上藤裕里加
• 通讯作者: 上藤裕里加

Treatment of nonalcoholic steatohepatitis with vitamins E and C: a pilot study.

• DOI: 10.2147/hmer.s41258
• 发表时间: 2013
• 期刊: Hepatic medicine : evidence and research
• 作者: Kawanaka M;Nishino K;Nakamura J;Suehiro M;Goto D;Urata N;Oka T;Kawamoto H;Nakamura H;Yodoi J;Hino K;Yamada G
• 通讯作者: Yamada G

急性腎障害(AXI)の病因別診断に尿中チオレドキシンが有用である

尿硫氧还蛋白有助于急性肾损伤（AXI）的病因诊断

• 发表时间: 2011
• 作者: 糟野健司;ら
• 通讯作者: ら

Nuclear expression of thioredoxin-1 in the invasion front is associated with outcome in patients with gallbladder carcinoma

• DOI: 10.1111/j.1477-2574.2012.00482.x
• 发表时间: 2012-09-01
• 期刊: HPB
• 影响因子: 2.9
• 作者: Nagano, Motoaki;Hatakeyama, Kinta;Chijiiwa, Kazuo
• 通讯作者: Chijiiwa, Kazuo