The significance of vaspin in metabolic syndrome and drug discovery

Vaspin是从肥胖大鼠内脏脂肪组织中发现的一种新的脂肪细胞因子。血管紧张素转换酶可改善代谢综合征患者的胰岛素抵抗和动脉粥样硬化的发展。Vaspin在人体血清中循环存在，并与体重指数、胰岛素抵抗程度呈正相关。2型糖尿病患者血清vaspin水平明显高于正常对照组。Vaspin对血清浓度的调节不同于瘦素和脂联素，vaspin可能成为代谢综合征治疗的新靶点。

Vaspin is a novel adipocytokine, which was identified from visceral adipose tissues in obese rats. Vaspin ameliorates the insulin resistance and development of atherosclerosis in metabolic syndrome. Vaspin circulates in the sera of human subjects and it positively correlated with body mass index and degree of insulin resistance. Serum levels of vaspin were higher in patients with type 2 diabetes compared with normal healthy subjects. The regulation of serum concentration of vaspin is different from leptin and adiponectin, and vaspin may be a new therapeutic target for metabolic syndrome.