The significance of vaspin in metabolic syndrome and drug discovery

Vaspin 在代谢综合征和药物发现中的意义

• 批准号: 23390241
• 负责人: WADA Jun
• 金额: $ 12.31万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390241/
• 关键词: メタボリックシンドローム; インスリン抵抗性; アディポカイン; バスピン; 糖尿病; 脂質異常症; 高血圧; 肥満症; 肥満

Vaspin is a novel adipocytokine, which was identified from visceral adipose tissues in obese rats. Vaspin ameliorates the insulin resistance and development of atherosclerosis in metabolic syndrome. Vaspin circulates in the sera of human subjects and it positively correlated with body mass index and degree of insulin resistance. Serum levels of vaspin were higher in patients with type 2 diabetes compared with normal healthy subjects. The regulation of serum concentration of vaspin is different from leptin and adiponectin, and vaspin may be a new therapeutic target for metabolic syndrome.

Vaspin是从肥胖大鼠内脏脂肪组织中发现的一种新的脂肪细胞因子。Vaspin可改善代谢综合征中的胰岛素抵抗和动脉粥样硬化的发展。Vaspin在人类受试者的血清中循环，并且它与体重指数和胰岛素抵抗程度正相关。2型糖尿病患者血清vaspin水平高于正常健康人。vaspin对血清浓度的调节作用与瘦素、脂联素不同，可能成为代谢综合征治疗的新靶点。

项目成果

ACAM (Adipocyte Adhesion Molecule) / CLMP Inhibits Adipocyte Hypertrophy in Obesity

ACAM（脂肪细胞粘附分子）/CLMP 抑制肥胖症中的脂肪细胞肥大

• 发表时间: 2013
• 作者: Murakami K;Wada J;Eguchi J;Ogawa D;Terami T;Terami N;Makino H
• 通讯作者: Makino H

The pathological role of galectin-9 in metabolic syndrome

Galectin-9 在代谢综合征中的病理作用

• 发表时间: 2013
• 作者: Teshigawara S;Wada J;Kanzaki M;Nakatsuka A;Murakami K;Katayama A;Terami T;Inoue K;Eguchi J;Makino H
• 通讯作者: Makino H

糖尿病×CKD診療ガイド

糖尿病 x CKD 治疗指南

• 发表时间: 2012
• 作者: Kurahashi H;Wang JW;Ishii A;Kojima T;Wakai S;Kizawa T;Fujimoto Y;Kikkawa K;Yoshimura K;Inoue T;Yasumoto S;Ogawa A;Kaneko S;Hirose S.;Hiromitsu Nakauchi;槇野博史
• 通讯作者: 槇野博史

Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease.

2型糖尿病和慢性肾脏疾病的患者的血清乳糖素-9水平升高。

• DOI: 10.1186/1471-2369-14-23
• 发表时间: 2013-01-22
• 期刊: BMC nephrology
• 影响因子: 2.3
• 作者: Kurose Y;Wada J;Kanzaki M;Teshigawara S;Nakatsuka A;Murakami K;Inoue K;Terami T;Katayama A;Watanabe M;Higuchi C;Eguchi J;Miyatake N;Makino H
• 通讯作者: Makino H

The serum vaspin levels are reduced in Japanese chronic hemodialysis patients.

• DOI: 10.1186/1471-2369-13-163
• 发表时间: 2012-12-03
• 期刊: BMC nephrology
• 影响因子: 2.3
• 作者: Inoue J;Wada J;Teshigawara S;Hida K;Nakatsuka A;Takatori Y;Kojo S;Akagi S;Nakao K;Miyatake N;McDonald JF;Makino H
• 通讯作者: Makino H