The role of vaspin in metabolic syndrome

Vaspin 在代谢综合征中的作用

• 批准号: 20390257
• 负责人: WADA Jun
• 金额: $ 11.9万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390257/
• 关键词: メタボリックシンドローム; インスリン抵抗性; アディポカイン; バスピン; 糖尿病; 脂質異常症; 高血圧; 肥満症; メタボリック症候群; 肥満

Vaspin is a novel adipocytokine, which was identified from visceral adipose tissues in obese rats. The injection of recombinant vaspin into obese mice and experiments using vaspin transgenic and knockout mice revealed that vaspin is a compensatory factor for insulin resistance in metabolic syndrome. Vaspin circulated in the sera of human subjects and it positively correlated with body mass index and degree of insulin resistance. Serum levels of vaspin were higher in patients with type 2 diabetes compared with normal healthy subjects. The regulation of serum concentration of vaspin differed from leptin and adiponectin and vaspin may be a new therapeutic target for metabolic syndrome.

Vaspin是从肥胖大鼠内脏脂肪组织中发现的一种新的脂肪细胞因子。将重组vaspin注射到肥胖小鼠中以及使用vaspin转基因和敲除小鼠的实验表明，vaspin是代谢综合征中胰岛素抵抗的补偿因子。Vaspin在人类受试者的血清中循环，并且与体重指数和胰岛素抵抗程度呈正相关。2型糖尿病患者血清vaspin水平高于正常健康人。vaspin对血清浓度的调节作用不同于瘦素和脂联素，可能成为代谢综合征治疗的新靶点。

项目成果

Serpins and Protein Kinase Inhibitors : Novel Functions, Structural Features and Molecular Mechanisms

丝氨酸蛋白酶抑制剂和蛋白激酶抑制剂：新功能、结构特征和分子机制

• 发表时间: 2009
• 作者: 近藤龍也;荒木栄一;et al.;Wada J
• 通讯作者: Wada J

INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese.

• DOI: 10.1007/s10038-008-0317-8
• 发表时间: 2008
• 期刊: JOURNAL OF HUMAN GENETICS
• 影响因子: 3.5
• 作者: Hotta, Kikuko;Nakamura, Michihiro;Nakata, Yoshio;Matsuo, Tomoaki;Kamohara, Seika;Kotani, Kazuaki;Komatsu, Ryoya;Itoh, Naoto;Mineo, Ikuo;Wada, Jun;Masuzaki, Hiroaki;Yoneda, Masato;Nakajima, Atsushi;Miyazaki, Shigeru;Tokunaga, Katsuto;Kawamoto, Manabu;Funahashi, Tohru;Hamaguchi, Kazuyuki;Yamada, Kentaro;Hanafusa, Toshiaki;Oikawa, Shinichi;Yoshimatsu, Hironobu;Nakao, Kazuwa;Sakata, Toshiie;Matsuzawa, Yuji;Tanaka, Kiyoji;Kamatani, Naoyuki;Nakamura, Yusuke
• 通讯作者: Nakamura, Yusuke

Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population

• DOI: 10.1038/jhg.2009.106
• 发表时间: 2009-12-01
• 期刊: JOURNAL OF HUMAN GENETICS
• 影响因子: 3.5
• 作者: Hotta, Kikuko;Nakamura, Michihiro;Nakamura, Yusuke
• 通讯作者: Nakamura, Yusuke

Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population

• DOI: 10.1038/jhg.2010.99
• 发表时间: 2010-11-01
• 期刊: JOURNAL OF HUMAN GENETICS
• 影响因子: 3.5
• 作者: Hotta, Kikuko;Nakamura, Michihiro;Kamatani, Naoyuki
• 通讯作者: Kamatani, Naoyuki

Glycated albumin levels predict long-term survival in diabetic patients undergoing hemodialysis.

糖化白蛋白水平预测接受血液透析的糖尿病患者的长期生存。

• 发表时间: 2008
• 期刊: Nephrology (Carlton) 13(4)
• 作者: Fukuoka K;Nakao K;Morimoto H;Nakao A;Takatori Y;Arimoto K;Taki M;Wada J;Makino H
• 通讯作者: Makino H