The role of vaspin in metabolic syndrome

Vaspin是从肥胖大鼠内脏脂肪组织中发现的一种新的脂肪细胞因子。将重组vaspin注射到肥胖小鼠中，以及使用vaspin转基因和敲除小鼠进行的实验表明，vaspin是代谢综合征中胰岛素抵抗的一种补偿因子。Vaspin在人体血清中循环，并与体重指数、胰岛素抵抗程度呈正相关。2型糖尿病患者血清vaspin水平明显高于正常对照组。Vaspin对血清瘦素、脂联素浓度的调节不同于脂联素，vaspin可能成为代谢综合征治疗的新靶点。

Vaspin is a novel adipocytokine, which was identified from visceral adipose tissues in obese rats. The injection of recombinant vaspin into obese mice and experiments using vaspin transgenic and knockout mice revealed that vaspin is a compensatory factor for insulin resistance in metabolic syndrome. Vaspin circulated in the sera of human subjects and it positively correlated with body mass index and degree of insulin resistance. Serum levels of vaspin were higher in patients with type 2 diabetes compared with normal healthy subjects. The regulation of serum concentration of vaspin differed from leptin and adiponectin and vaspin may be a new therapeutic target for metabolic syndrome.