Investigation of mechanism of systemic diseases caused by oral bacteria and development of preventive procedures
Investigation of mechanism of systemic diseases caused by oral bacteria and development of preventive procedures
批准号:
23390472
负责人:
OOSHIMA Takashi
金额:
$12.31万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31
中文摘要
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英文摘要
Recently, the association of periodontitis with several systemic diseases has received attention. In the present study, the contribution of Streptococcus mutans, a major pathogen of dental caries, to the pathogenesis of infective endocarditis, cerebral hemorrhage, inflammatory bowel disease, and non-alcoholic steatohepatitis was investigated by focusing on cell surface collagen-binding proteins. Our results showed that S. mutans with collagen-binding proteins is possibly virulent for these diseases following invsion of the bloodstream.
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Characterization of aortic aneurysm in cardiovascular disease patients harboring Porphyromonas gingivalis
携带牙龈卟啉单胞菌的心血管疾病患者主动脉瘤的特征
DOI:
--
发表时间:
2011
期刊:
Oral Dis
影响因子:
3.8
作者:
[Nakano K, Wada K, Nomura R, Nemoto H, Inaba H, Kojima A, Naka S, Hokamura K, Mukai T, Hata H, Toda K, Nakajima A, Umemura K, Kamisaki Y, Yoshioka H, Taniguchi K, Amano A, Ooshima T]
通讯作者:
Ooshima T
Specific Streptococcus mutans strain aggravates non-alcoholic fatty liver disease.
特定的变形链球菌菌株会加重非酒精性脂肪肝。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Naka S, Nomura R, Ooshima T, Nakano K.]
通讯作者:
Nakano K.
高病原性う蝕原因菌Streptococcus mutans 由来のリコンビナントタンパクによって脳出血が増悪する
来自高致病性致龋菌变形链球菌的重组蛋白会加剧脑出血
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[外村和也, 仲野和彦, 野村良太, 大嶋 隆, 大橋寿彦, 細井泰志, 田中篤太郎, 梅村和夫]
通讯作者:
梅村和夫
DOI:
10.1099/jmm.0.027615-0
发表时间:
2011-12-01
期刊:
JOURNAL OF MEDICAL MICROBIOLOGY
影响因子:
3
作者:
[Nemoto, Hirotoshi, Nakano, Kazuhiko, Ooshima, Takashi]
通讯作者:
Ooshima, Takashi
DOI:
10.1111/odi.12191
发表时间:
2014-10-01
期刊:
ORAL DISEASES
影响因子:
3.8
作者:
[Naka, S., Nomura, R., Nakano, K.]
通讯作者:
Nakano, K.
共 52 条
Analysis of virulence factors in cariogenic bacteria for cardiovascular diseases
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批准号:19209063
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.7万
-
财政年份:2007
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负责人:OOSHIMA Takashi
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依托单位:
Molecular analysis of cell surface structures of Streptococcus mutans for virulence of infective endocarditis
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批准号:16390605
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.09万
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财政年份:2004
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负责人:OOSHIMA Takashi
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依托单位:
MOLECULAR BIOLOGICAL ANALYSIS OF SUCROSE-DEPENDENT ADHERENCE IN STREPTOCOCCUS MUTANS
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批准号:14370693
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.96万
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财政年份:2002
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负责人:OOSHIMA Takashi
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依托单位:
RESEARCH ON PREDICTION OF PERIODONTAL DISEASE IN CHILDREN AND ADOLESCENTS
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批准号:11557165
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.45万
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财政年份:1999
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负责人:OOSHIMA Takashi
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依托单位:
The cause of dentinal defects in heritable hypophosphatemic vitamin D-resistant rickets
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批准号:11470450
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.23万
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财政年份:1999
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负责人:OOSHIMA Takashi
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依托单位:
Detection of anti-caries substances in oolong tea extract
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批准号:09672102
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:1997
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负责人:OOSHIMA Takashi
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依托单位:
Development of Passive Immunization System Against Dental Caries by Hen Egg Yolk Antibodies of Streptococcus Mutans.
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批准号:01870089
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项目类别:Grant-in-Aid for Developmental Scientific Research (B).
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资助金额:$7.1万
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财政年份:1989
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负责人:OOSHIMA Takashi
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依托单位:
Transmission and Establishment of Streptococcus mutans in an animal experimental system.
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批准号:62570915
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.22万
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财政年份:1987
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负责人:OOSHIMA Takashi
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依托单位:
海外基金