Development of minimally invasive strategy for in-stent restenosis for peripheral arterial disease

外周动脉疾病支架内再狭窄微创策略的开发

• 批准号: 23500565
• 负责人: OBARA HIDEAKI
• 金额: $ 3.16万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500565/
• 关键词: 動脈硬化; 内膜肥厚; ステント; 再狭窄; フリーラジカル; 低侵襲治療; 外部エネルギー

Aim of this study is to develop minimally invasive strategy for preventing in-stent restenosis of peripheral arterial disease.The generation of heat was obtained by magnetic field irradiation to a nickel-titanium alloy (nitinol) stent at 200kHz or 900kHz/4mT in in vitro, but we could not reach to the stage of animal experiments due to construction of magnetic field generator. The generation of the free radicals was observed by ultrasound irradiation to a nitinol stent at 500kHz or 1MHz. Free radicals were effective to suppress the in-stent stenosis on xenograft model (subcutaneous tumor model). WHHLMI rabbit exhibits hereditary hyperlipidemia and arteriosclerosis. In the rabbit intimal thickening model, the main artery of the WHHLMI rabbit rubbed with Fogarty catheter, and then, nitinol stent was inserted after two weeks from the treatment. There was no restenosis after one month from insersion, thereby the model was extended up to six months and are currently being analyzed.

本研究旨在探索预防外周动脉疾病支架内再狭窄的微创方法。本研究采用200 kHz或900 kHz/4mT磁场照射镍钛合金(镍钛合金)支架，在体外产生热量，但由于磁场发生器的搭建，尚不能达到动物实验阶段。用500 kHz或1 MHz的超声波照射镍钛合金支架，观察自由基的产生。在异种移植模型(皮下肿瘤模型)上，自由基能有效抑制支架内狭窄。WHHLMI兔表现为遗传性高脂血症和动脉硬化。在兔动脉内膜增厚模型中，用Fogarty导管摩擦WHHLMI兔的主动脉，治疗2周后置入镍钛合金支架。植入后一个月没有再狭窄，因此该模型被延长到六个月，目前正在进行分析。