Transcriptional regulation of CCR7 expression in mature T-cell malignancies

之前，我们研究了成人t细胞白血病/淋巴瘤（ATL）中CCR4表达的转录调控，并证明AP-1家族成员FRA-2在ATL中异常表达，并与JUND相关，促进CCR4的表达和细胞生长，同时上调ATL中各种原癌基因如c-Myb和SOX4。在本研究中，我们将我们的分析扩展到ATL和皮肤T细胞淋巴瘤（CTCLs）中高表达的CCR7，并在CCR7启动子中发现了一个新的dna结合元件GAGGAG，以及ZFYVE19与该元件的结合。我们的研究表明ATL和ctcl中存在另一种致癌级联，为成熟T细胞恶性肿瘤的诊断和治疗提供了有用的信息。

Previously, we have examined the transcriptional regulation of CCR4 expression in adult T-cell leukemia/lymphoma (ATL) and demonstrated that an AP-1 family member FRA-2 is aberrantly expressed in ATL and in association with JUND promotes CCR4 expression and cell growth together with upregulation of various proto-oncogenes such as c-Myb and SOX4 in ATL. In the present study, we have extended our analysis to CCR7, which is highly expressed in ATL and cutaneous T cell lymphomas (CTCLs), and found a novel DNA-binding element GAGGAG in the CCR7 promoter and binding of ZFYVE19 to this element. Our study suggests an existence of another oncogenic cascade in ATL and CTCLs, providing useful information on the diagnosis and treatment of mature T cell malignancies.