Transcriptional regulation of CCR7 expression in mature T-cell malignancies

成熟 T 细胞恶性肿瘤中 CCR7 表达的转录调控

• 批准号: 23501273
• 负责人: YOSHIE Osamu
• 金额: $ 3.16万
• 依托单位: Kinki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23501273/
• 关键词: CCR7; ケモカイン; 転写因子; 成人T細胞白血病／リンパ腫（ATL）; 皮膚T細胞リンパ腫（CTCL）; ATL; CTCL; c-Myb; ATLL

Previously, we have examined the transcriptional regulation of CCR4 expression in adult T-cell leukemia/lymphoma (ATL) and demonstrated that an AP-1 family member FRA-2 is aberrantly expressed in ATL and in association with JUND promotes CCR4 expression and cell growth together with upregulation of various proto-oncogenes such as c-Myb and SOX4 in ATL. In the present study, we have extended our analysis to CCR7, which is highly expressed in ATL and cutaneous T cell lymphomas (CTCLs), and found a novel DNA-binding element GAGGAG in the CCR7 promoter and binding of ZFYVE19 to this element. Our study suggests an existence of another oncogenic cascade in ATL and CTCLs, providing useful information on the diagnosis and treatment of mature T cell malignancies.

之前，我们研究了成人t细胞白血病/淋巴瘤（ATL）中CCR4表达的转录调控，并证明AP-1家族成员FRA-2在ATL中异常表达，并与JUND相关，促进CCR4的表达和细胞生长，同时上调ATL中各种原癌基因如c-Myb和SOX4。在本研究中，我们将我们的分析扩展到ATL和皮肤T细胞淋巴瘤（CTCLs）中高表达的CCR7，并在CCR7启动子中发现了一个新的dna结合元件GAGGAG，以及ZFYVE19与该元件的结合。我们的研究表明ATL和ctcl中存在另一种致癌级联，为成熟T细胞恶性肿瘤的诊断和治疗提供了有用的信息。

项目成果

Selective down-regulation of Th2 cell-mediated airway inflammation in mice by pharmacological intervention of CCR4

• DOI: 10.1111/j.1365-2222.2011.03847.x
• 发表时间: 2012-02-01
• 期刊: CLINICAL AND EXPERIMENTAL ALLERGY
• 影响因子: 6.1
• 作者: Kaminuma, O.;Ohtomo, T.;Hiroi, T.
• 通讯作者: Hiroi, T.

Generation of colonic IgA-secreting cells in the caecal patch

• DOI: 10.1038/ncomms4704
• 发表时间: 2014-04-01
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Masahata, Kazunori;Umemoto, Eiji;Takeda, Kiyoshi
• 通讯作者: Takeda, Kiyoshi

Fra-2-SOX4 oncogenic cascade plays a critical role in cell growth of adult T-cell leukemia/lymphoma

Fra-2-SOX4 致癌级联在成人 T 细胞白血病/淋巴瘤的细胞生长中发挥关键作用

• 发表时间: 2013
• 作者: Higuchi T;Nakayama T;Yoshie O
• 通讯作者: Yoshie O

Induction of FosB by Tax induces CCL22 in HTLV-1-infected T cells, leading to HTLV-1

通过 Tax 诱导 FosB 会在 HTLV-1 感染的 T 细胞中诱导 CCL22，从而产生 HTLV-1

• 发表时间: 2012
• 作者: Higuchi T;Hieshima K;Nakayama T;Yoshie O
• 通讯作者: Yoshie O

Expression and function of FRA2/JUND in cutaneous T-cell lymphomas

FRA2/JUND在皮肤T细胞淋巴瘤中的表达和功能

• 发表时间: 2012
• 期刊: Anticancer Res
• 影响因子: 2
• 作者: Nakayama T;Higuchi T;Oiso N;Kawada A;Yoshie O
• 通讯作者: Yoshie O