Study on the pathophysiological role of the Th2-type chemokine receptor CCR4

CCR 4是由Th 2细胞、调节性T细胞和皮肤归巢T细胞选择性表达的趋化因子受体。我们已经证明了小分子CCR 4抑制剂对Th 2诱导的小鼠气道炎症的有效治疗作用。我们还发现，CCR 4及其配体MDC/CCL 22介导肠系膜淋巴结中树突状细胞和调节性T细胞的免疫抑制相互作用。此外，人致癌病毒如EBV和HTLV-1通常诱导MDC/CCL 22在感染的宿主细胞中的表达，以吸引Th 2细胞和调节性T细胞用于免疫逃避和病毒繁殖。

CCR4 is a chemokine receptor selectively expressed by Th2 cells, regulatory T cells, and skin-homing T cells. We have shown a potent ther apeutic effect of a small molecule CCR4 inhibitor on Th2-induced airway inflammation in mice. We have also shown that CCR4 and its ligand MDC/CCL22 mediate immunosuppressive interactions of dendritic cells and regulatory T cells in mesenteric lymphonodes. Furthermore, human oncogenic viruses such as EBV and HTLV-1 commonly induce expression of MDC/CCL22 in infected host cells to attract Th2 cells and regulatory T cells for immunoevasion and virus propagation.