Study on mechanisms of toxicity for nitro-phenols found in diesel exhaust on adrenal grand and reproductive organs, and risks for activating mammary carcinoma cells.

研究柴油机尾气中硝基酚对肾上腺和生殖器官的毒性机制以及激活乳腺癌细胞的风险。

• 批准号: 23510073
• 负责人: WATANABE Gen
• 金额: $ 3.49万
• 依托单位: Tokyo University of Agriculture and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23510073/
• 关键词: ニトロフェノール; 環境; 生殖毒性; ディーゼル排気ガス

Although PNMPP did not show effects on the basal secretion of FSH and LH from pituitary cells of immature male rats, secretion of both hormones stimulated by GnRH were decreased by adding PNMPP. PNMPP stimulated testosterone secretion from Leydig cells and enhanced the response to the hCG in vitro. PNMMPP was proved to have anti-androgenic effects in vivo using castrated immature male rats supplemented with testosterone.PNMC and PNP stimulated proliferation of normal mammary epithelial cells in mice, but did not for cells derived from mammary tumor of both mice and human. Nitrophenols failed to show effects on sexual differentiation of the brain in the rat.

虽然PNMPP对未成熟雄性大鼠垂体细胞的FSH和LH基础分泌没有显示出影响，但添加PNMPP后GnRH刺激的两种激素的分泌均减少。 PNMPP 刺激 Leydig 细胞分泌睾酮，并增强体外对 hCG 的反应。使用补充睾酮的未成熟雄性大鼠在体内证明PNMMPP具有抗雄激素作用。PNMC和PNP刺激小鼠正常乳腺上皮细胞的增殖，但对小鼠和人类乳腺肿瘤来源的细胞没有刺激作用。硝基酚未能显示出对大鼠大脑性别分化的影响。

项目成果

Effect of nanoparticle-rich diesel exhaust on testosterone biosynthesis in adult male mice

• DOI: 10.3109/08958378.2012.702140
• 发表时间: 2012-08-01
• 期刊: INHALATION TOXICOLOGY
• 影响因子: 2.1
• 作者: Li, ChunMei;Li, Xuezheng;Taya, Kazuyoshi
• 通讯作者: Taya, Kazuyoshi

Effects of exposure to nanoparticle-rich diesel exhaust on adrenocortical function in adult male mice

• DOI: 10.1016/j.toxlet.2012.01.004
• 发表时间: 2012-03-25
• 期刊: TOXICOLOGY LETTERS
• 影响因子: 3.5
• 作者: Li, ChunMei;Li, Xuezheng;Taya, Kazuyoshi
• 通讯作者: Taya, Kazuyoshi

Neonatal exposure to 17α-ethynyl estradiol affects ovarian gene expression and disrupts reproductive cycles in female rats

• DOI: 10.1016/j.reprotox.2014.03.001
• 发表时间: 2014-07-01
• 期刊: REPRODUCTIVE TOXICOLOGY
• 影响因子: 3.3
• 作者: Nozawa, Kaori;Nagaoka, Kentaro;Watanabe, Gen
• 通讯作者: Watanabe, Gen

雌ラットの脳性分化臨界期におけるエストロジェン投与が成熟後の生殖機能に及ぼす遅発性影響．

雌性大鼠大脑性别分化关键期雌激素给药对成熟后生殖功能的延迟影响。

• 发表时间: 2012
• 作者: 野澤香織;永岡謙太郎;吉田緑;田谷一善;渡辺元．
• 通讯作者: 渡辺元．

Effect of nanoparticle-rich diesel exhaust on testicular and hippocampus steroidogenesis.

富含纳米颗粒的柴油机尾气对睾丸和海马类固醇生成的影响。

• 发表时间: 2012
• 期刊: Inhalation Toxicology
• 影响因子: 2.1
• 作者: Yamagishi N;Ito Y;Ramdhan DH;Yanagiba Y;Hayashi Y;Dong W;Li CM;Taneda S;Suzuki AK;Taya K;Watanabe G;Kamijima M & Nakajima T.
• 通讯作者: Kamijima M & Nakajima T.