Study on mechanisms of toxicity for nitro-phenols found in diesel exhaust on adrenal grand and reproductive organs, and risks for activating mammary carcinoma cells.

虽然PNMPP对未成熟雄性大鼠垂体细胞FSH和LH的基础分泌没有影响，但添加PNMPP后，GnRH刺激的两种激素的分泌均减少。PNMPP刺激间质细胞分泌睾酮，增强对hCG的反应。PNMMPP在被阉割的未成熟雄性大鼠体内补充睾酮，被证明具有抗雄激素作用。PNMC和PNP均能刺激小鼠正常乳腺上皮细胞的增殖，但对小鼠和人乳腺肿瘤细胞均无刺激作用。硝基酚对大鼠大脑的性别分化没有影响。

Although PNMPP did not show effects on the basal secretion of FSH and LH from pituitary cells of immature male rats, secretion of both hormones stimulated by GnRH were decreased by adding PNMPP. PNMPP stimulated testosterone secretion from Leydig cells and enhanced the response to the hCG in vitro. PNMMPP was proved to have anti-androgenic effects in vivo using castrated immature male rats supplemented with testosterone.PNMC and PNP stimulated proliferation of normal mammary epithelial cells in mice, but did not for cells derived from mammary tumor of both mice and human. Nitrophenols failed to show effects on sexual differentiation of the brain in the rat.