Synthetic and Mechanistic Applications of Asymmetric Oxidation with Chiral Hypervalent Iodine

邻烯基苯甲酸酯在高价碘试剂作用下的氧代内酯反应，选择性地生成4-氧基异色满-1-酮。使用以乳酸为基础的高价碘试剂进行氧酰化反应，获得了高水平的对映体选择性。为了证明高价碘介导的氧-内酰化反应作为一种独特的合成策略的可行性，我们在这里公开了一个简明的条目4-氧基异色曼-1-酮聚酮代谢物，其中包含单角蛋白的衍生物和与褐藻素相关的天然产物。

Oxylactonization of ortho-alkenylbenzoates with hypervalent iodine reagent selectively gave 4-oxyisochroman-1-one products. High level of enantioselectivity was achieved using a lactate-based hypervalent iodine reagent for the oxylactonization. In order to demonstrate the expediency of hypervalent iodine-mediated oxylactonization as a unique synthetic strategy, here we disclose a concise entry to 4-oxyisochroman-1-one polyketide metabolites, containing monocerin derivatives and a fusarentin-related natural product.