Synthetic and Mechanistic Applications of Asymmetric Oxidation with Chiral Hypervalent Iodine

邻位烯基苯甲酸酯与高价碘试剂的氧内酰化反应选择性地得到4-氧异色满-1-酮产物。高水平的对映体选择性，实现了使用乳酸盐为基础的高价碘试剂的α-内酯化。为了证明作为一种独特的合成策略的高价碘介导的β-内酯化的便利性，在这里，我们公开了一个简明的条目4-氧异色满-1-酮聚酮代谢物，含有monocerin衍生物和fusarentin相关的天然产物。

Oxylactonization of ortho-alkenylbenzoates with hypervalent iodine reagent selectively gave 4-oxyisochroman-1-one products. High level of enantioselectivity was achieved using a lactate-based hypervalent iodine reagent for the oxylactonization. In order to demonstrate the expediency of hypervalent iodine-mediated oxylactonization as a unique synthetic strategy, here we disclose a concise entry to 4-oxyisochroman-1-one polyketide metabolites, containing monocerin derivatives and a fusarentin-related natural product.