An Investigation of Design Method on a Light Waveguide Incorporated Optical Total Analysis System

光波导一体化光学全分析系统设计方法研究

• 批准号: 23560299
• 负责人: OHKUBO Toshifumi
• 金额: $ 3万
• 依托单位: Toyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23560299/
• 关键词: TAS（総合分析システム）; マイクロ流路; 光導波路; FDTD法; BPM法; 前方散乱光; 側方散乱光; TAS; FDTD 法

Assuming the realization of a ubiquitous human healthcare system in the near future society, I performed the research of realizing principal functions of high-end cell analyzer like a flow-cytometer into a minute total analysis system (TAS) chip which consists of both micro fluidic channels and light waveguides. Our fundamental concept of realizing this novel TAS utilized for the healthcare system is founded on the technologies of resin-based light waveguide that is already applied to a high-speed signal processing circuit board. Carefully fabricating minute fluidic channels on a surface of waveguide-formed resin layer could make it possible to properly and precisely illuminate cells or particles running along a fluidic channel, and finally, through a series of experiments of detecting extremely weak scattered light, we could successfully confirm fundamental functions to evaluate optical properties of a pseudo-cell, utilizing trial-manufactured resin-based TAS chips.

假设在不久的将来社会中实现无处不在的人类医疗保健系统，我进行了将高端细胞分析仪（如流式细胞仪）的主要功能实现到由微流体通道和光波导组成的微型全分析系统（TAS）芯片中的研究。我们实现这种用于医疗保健系统的新型TAS的基本概念是基于已经应用于高速信号处理电路板的树脂基光波导技术。在波导形成的树脂层的表面上仔细地制造微小的流体通道可以使得能够适当且精确地照射沿着流体通道运行的细胞或颗粒，并且最后，通过检测极弱散射光的一系列实验，我们可以利用试制的基于树脂的TAS芯片成功地确认基本功能以评估伪细胞的光学性质。

项目成果

Illumination and scattered light detection using a light source consisting of sub-micrometer defect arrays formed on an extremely flat light waveguide core

使用由在极其平坦的光波导芯上形成的亚微米缺陷阵列组成的光源进行照明和散射光检测

• 发表时间: 2013
• 作者: 加藤;前田;岩崎;平井;Takafumi Matsumaru;Toshifumi Ohkubo
• 通讯作者: Toshifumi Ohkubo

東洋大学 研究者情報データベース

东洋大学研究员信息数据库

Illumination and scattered light detection using a light source consisting of sub-micrometer defect arrays formed on a extremely flat light waveguide core

使用由在极其平坦的光波导芯上形成的亚微米缺陷阵列组成的光源进行照明和散射光检测

• DOI: 10.1007/s00542-014-2132-9
• 发表时间: 2014
• 期刊: Microsystem Technologies
• 作者: Toshifumi Ohkubo;Nobuyuki Terada;Yoshikazu Yoshida
• 通讯作者: Yoshikazu Yoshida

Illumination and scattered light detection of a minute particle using a light source consisting of sub-micrometer defect arrays formed on an extremely flat waveguide core

使用由在极其平坦的波导芯上形成的亚微米缺陷阵列组成的光源对微小颗粒进行照明和散射光检测

• 发表时间: 2013
• 作者: T. Ohkubo;N. Terada;Y. Yoshida
• 通讯作者: Y. Yoshida

Improvement of an Optical and Fluidic Path Crossing Type Total Analysis System (TAS),

光学和流体路径交叉型全分析系统（TAS）的改进，

• 作者: T. Ohkubo;N. Terada;Y. Yoshida
• 通讯作者: Y. Yoshida