Roles of a vesicular transport network and a membrane fusion in autophagy in Saccharomyces cerevisiae

我们发现，自噬被抑制时，分泌途径被阻断在几个SNARE（可溶性NSF附着蛋白受体）突变体，这表明从分泌途径的膜脂供应可能是重要的自噬体的形成。我们还发现，一些SNARE蛋白直接与Atg 9相关，Atg 9在自噬体形成中起作用，在自噬体前结构中，这表明这些蛋白可能作为自噬体形成的机制发挥作用。

We found that autophagy was inhibited when the secretory pathway was blocked in several SNARE (soluble NSF attachment protein receptor) mutants, suggesting that a supply of membrane lipid from the secretory pathway might be important for autophagosome formation. We also showed that some SNARE proteins directly associated with Atg9, which plays roles in autophagosome formation, at preautophagosomal structure, suggesting that these proteins might function as machinery of autophagosome formation.