Clarification of the natural host defense system against indigenous bacteria in alimentary tract

动物天然宿主防御本地细菌（IB）的研究成果如下：澄清小肠和大肠中IB沉降与膜性toll样受体(mTLRs)/分泌性TLRs （sTLRs）之间的关系，澄清小肠中IB沉降的变化与抗菌物质分泌之间的关系，澄清肠相关淋巴组织中滤泡相关肠隐窝的特殊上皮分化，阐明了宿主通过上皮细胞凋亡对食道和表皮中IB过度增殖的详细防御，证明了乳糜微粒从肠上皮直接运输到肝门静脉血液和乳糜微粒运输的内皮受体，阐明了呼吸道中mTLRs的识别系统和sTLRs对IB的分泌。

The research achievements on the natural host defense against indigenous bacteria (IB) in animals is as follows: the clarification of the relationship between IB settlement and membranous Toll-like receptor (mTLRs)/secretory TLRs (sTLRs) in small and large intestines, the clarification of the relationship between the alternation of IB settlement and the bactericidal substance secretion in small intestine, the clarification of the peculiar epithelial differentiation in the follicle-associated intestinal crypts of gut-associated lymphatic tissue, the clarification of the detailed host defense with epithelial apoptosis against IB hyperproliferation in esophagus and epidermis, the demonstration of the direct transportation of chylomicrons from the intestinal epithelium into the hepatic portal blood and the endothelial receptor for chylomicron transportation, the clarification of the recognition system with mTLRs and secretion of sTLRs against IB in the respiratory tract.