Clarification of the natural host defense system against indigenous bacteria in alimentary tract

阐明针对消化道本土细菌的天然宿主防御系统

• 批准号: 23580403
• 负责人: KITAGAWA Hiroshi
• 金额: $ 3.49万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23580403/
• 关键词: 生体防御機構; 消化管; 常在細菌; 自然免疫; Toll-like receptor; 免疫組織化学; 国際情報交流

The research achievements on the natural host defense against indigenous bacteria (IB) in animals is as follows: the clarification of the relationship between IB settlement and membranous Toll-like receptor (mTLRs)/secretory TLRs (sTLRs) in small and large intestines, the clarification of the relationship between the alternation of IB settlement and the bactericidal substance secretion in small intestine, the clarification of the peculiar epithelial differentiation in the follicle-associated intestinal crypts of gut-associated lymphatic tissue, the clarification of the detailed host defense with epithelial apoptosis against IB hyperproliferation in esophagus and epidermis, the demonstration of the direct transportation of chylomicrons from the intestinal epithelium into the hepatic portal blood and the endothelial receptor for chylomicron transportation, the clarification of the recognition system with mTLRs and secretion of sTLRs against IB in the respiratory tract.

动物天然宿主防御本地细菌（IB）的研究成果如下：澄清小肠和大肠中IB沉降与膜性toll样受体(mTLRs)/分泌性TLRs （sTLRs）之间的关系，澄清小肠中IB沉降的变化与抗菌物质分泌之间的关系，澄清肠相关淋巴组织中滤泡相关肠隐窝的特殊上皮分化，阐明了宿主通过上皮细胞凋亡对食道和表皮中IB过度增殖的详细防御，证明了乳糜微粒从肠上皮直接运输到肝门静脉血液和乳糜微粒运输的内皮受体，阐明了呼吸道中mTLRs的识别系统和sTLRs对IB的分泌。

项目成果

ラットの大腸粘膜上皮におけるToll-like receptorの発現と分泌

大鼠结肠粘膜上皮Toll样受体的表达和分泌

• 发表时间: 2011
• 作者: 星野重樹;他;万谷洋平，亀崎青沙，Udayanga Kankanam Gamage Sanath，高原英一郎，谷田任司，河野潤一，横山俊史，星 信彦，北川 浩
• 通讯作者: 万谷洋平，亀崎青沙，Udayanga Kankanam Gamage Sanath，高原英一郎，谷田任司，河野潤一，横山俊史，星 信彦，北川 浩

Site differences of the Toll-like receptor expression in the mucous epithelium of rat small intestine

大鼠小肠粘膜上皮Toll样受体表达位点差异

• 发表时间: 2011
• 期刊: Histology and Histopathology
• 影响因子: 2
• 作者: Mantani;Y.;Kamezaki;A.;Udayanga;K. G. S.;Takahara;E.;Qi;W.-M.;Yokoyama;T.;Kawano;J.;Hoshi;N.;Kitagawa;H.
• 通讯作者: H.

Immunohistochemical study of the apoptosis process in epidermal epithelial cells of rats under a physiological condition

• DOI: 10.14670/hh-26.811
• 发表时间: 2011-07-01
• 期刊: HISTOLOGY AND HISTOPATHOLOGY
• 影响因子: 2
• 作者: Udayanga, K. G. S.;Miyata, H.;Kitagawa, H.
• 通讯作者: Kitagawa, H.

Ultrastructural and histochemical study on the epithelial differentiation to Paneth cells in the rat ascending colon

大鼠升结肠上皮向潘氏细胞分化的超微结构和组织化学研究

• DOI: 10.1002/ar.22937
• 发表时间: 2014
• 期刊: Anatomical Record
• 作者: Mantani;Y.;Nishida;M.;Yuasa;H.;Yamamoto;K.;Takahara;E.;Omotehara;T.;Udayanga;K. G. S.;Kawano;J.;Yokoyama;T.;Hoshi;N. and Kitagawa;H.
• 通讯作者: H.

ラットの呼吸器粘膜におけるToll-like receptorの発現と分泌

大鼠呼吸道粘膜Toll样受体的表达和分泌

• 发表时间: 2011
• 作者: 亀崎 青沙;万谷 洋平;Udayanga Kankanam Gamage Sanath;高原 英一郎;谷田 任司;河野 潤一;横山 俊史;星 信彦;北川 浩
• 通讯作者: 北川 浩