Novel long-lasting kisspeptin derivatives stimulate luteinizing hormone secretion in bovine

Kisspeptin是一种肽类激素，通过刺激垂体的促黄体生成素（LH），作为生殖轴的主要正调节因子。为了开发新的药物，本研究对牛Kisspeptin的C-末端残基进行了各种修饰，以研究其是否能增强LH刺激能力，并具有持久的药理作用。一些修改诱导LH从培养的牛垂体细胞分泌到一个更大的程度和更长的持续时间比未修改的kisspeptin。接下来，我们尝试将最佳候选新药注射到小母牛和产后奶牛中。最好的候选刺激LH分泌的小母牛，虽然它没有显着影响产后奶牛LH分泌。因此，我们开发了新的长效kisspeptin衍生物刺激牛促黄体生成素分泌。

Kisspeptin is a peptide hormone that acts as the principal positive regulator of the reproductive axis by stimulating luteinizing hormone (LH) from pituitary. In order to develop new medicine, this study investigated whether various modification of the C-terminal residue of bovine kisspeptin can potentiate the LH-stimulating ability, and have long-lasting pharmacological effects. Some of modification induced the secretion of LH from cultured bovine pituitary cells to a greater degree and longer-lasting than unmodified kisspeptin. In next, we tried to inject the best candidate of new drugs into heifers and postpartum dairy cows. The best candidate stimulated LH secretion in heifers, although it had no significant effect on LH secretion in postpartum dairy cows. Therefore, we developed novel long-lasting kisspeptin derivatives stimulate luteinizing hormone secretion in bovine.