Search of the new anticancer drug material which makes tublin a molecular target from the marine invertebrate as

从海洋无脊椎动物中寻找使微管蛋白成为分子靶点的新型抗癌药物材料

• 批准号: 23590008
• 负责人: YAMADA Koji
• 金额: $ 3.49万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590008/
• 关键词: チューブリン; 抗がん剤; 海洋無脊椎動物; 棘皮動物; ナマコ; 海綿動物; 海洋性細菌; 海洋性真菌; フサコケムシ; ジケトピペラジン

In this application research, in order to develop the tubulin polymerization and the depolymerization inhibitory substance of the marine invertebrate as a seed compound of a new antineoplastic drug and to separate an active ingredient, the sea invertebrate animal was collected, each animal was processed, and the rough extract was obtained. Furthermore, the extract which has a possibility of having investigated the action on PC12 cell and having affected the tubulin function under nerve growth factor existence about the obtained sample as the first activity testing was found out. The active ingredient was searched about the sponges, sea cucumbers, and the cultivation extract of the bacteria further separated from Bugula neritina, that was accepted to be that activity will be shown. A ceramide, cerebrosides, and diketopiperazine derivatives have been separated. Synthesis of several sorts of analog objects, required in order to evaluate structure activity relationship, was also started.

在该应用研究中，为了开发海洋无脊椎动物的微管蛋白聚合和解聚抑制物质作为新药的种子化合物并分离活性成分，收集海洋无脊椎动物，对每个动物进行处理，并获得粗提物。此外，对于作为第一活性测试的所得样品，发现了在神经生长因子存在下可能已经研究了对PC 12细胞的作用并影响了微管蛋白功能的提取物。对海绵、海参和进一步从Bugula neritina分离的细菌的培养提取物进行了活性成分的搜索，认为其活性将被显示出来。已分离出神经酰胺、糖苷和二酮哌嗪衍生物。为了评估结构活性关系，还开始了几种模拟对象的合成。

项目成果

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二枚貝, 特にシジミの機能性因子に関する研究

双壳类特别是蚬类软体动物功能因子的研究

• 发表时间: 2013
• 期刊: New Food Industry
• 作者: 千々松武司;山田耕史;小田裕昭;望月 聡
• 通讯作者: 望月 聡

Lipid components prepared from a freshwater clam (Corbicula fluminea) extract ameliorate hypercholesterolemia in rats fed high-cholesterol diet.

从淡水蛤（Corbicula Fluminea）提取物中提取的脂质成分可改善高胆固醇饮食大鼠的高胆固醇血症。

• 发表时间: 2013
• 期刊: Food Chem.
• 作者: Chijimatsu;T.;Umeki;M.;Kataoka;Y.;Kobayashi;S,;Yamada;K.;Oda;H. and Mochizuki;S.
• 通讯作者: S.

海洋細菌由来の生物活性成分

源自海洋细菌的生物活性成分

• 发表时间: 2011
• 作者: Amgad IIbrahim Mansour Khedr;山田耕史;山田耕史
• 通讯作者: 山田耕史

チャオニテングダケ培地のジテルペノイド成分

毒蝇伞培养基中的二萜成分

• 作者: 麻野美帆;田中隆;松尾洋介;山田耕史;河野
• 通讯作者: 河野