Search of the new anticancer drug material which makes tublin a molecular target from the marine invertebrate as

在本应用研究中，为了开发海洋无脊椎动物微管蛋白聚合解聚抑制物质作为一种新型抗肿瘤药物的种子化合物，并分离出一种有效成分，采集海洋无脊椎动物，对每只动物进行加工，得到粗提物。进一步，发现所得样品在神经生长因子存在的情况下，有可能考察了其对PC12细胞的作用并影响了微管蛋白功能的提取物作为第一次活性检测。通过对海绵、海参和从海参中进一步分离出的细菌培养提取物的研究，发现其有效成分具有一定的活性。已分离出神经酰胺、脑苷和二酮哌嗪衍生物。同时还开始了评价结构活动关系所需的几种模拟对象的综合。

In this application research, in order to develop the tubulin polymerization and the depolymerization inhibitory substance of the marine invertebrate as a seed compound of a new antineoplastic drug and to separate an active ingredient, the sea invertebrate animal was collected, each animal was processed, and the rough extract was obtained. Furthermore, the extract which has a possibility of having investigated the action on PC12 cell and having affected the tubulin function under nerve growth factor existence about the obtained sample as the first activity testing was found out. The active ingredient was searched about the sponges, sea cucumbers, and the cultivation extract of the bacteria further separated from Bugula neritina, that was accepted to be that activity will be shown. A ceramide, cerebrosides, and diketopiperazine derivatives have been separated. Synthesis of several sorts of analog objects, required in order to evaluate structure activity relationship, was also started.