Creation of Artificial Oxygen Carrier Using Supramolecular Complex

人工氧载体的研制是保障稳定输血的关键。人工氧载体不存在血型或血液感染问题，其保存时间比血液本身更长。到目前为止开发的血液替代品主要来自血红蛋白和相关材料。肌红蛋白比血红蛋白具有优势，因为它不受溶液pH变构效应的影响。然而，由于肌红蛋白具有极高的氧亲和力，一直没有被用作血液替代品。我们已经开展了一项研究，为肌红蛋白提供适当的氧气运输能力，并将其用作有效的氧气载体。四吡咯在卟啉环上的重排对于控制氧的输送是非常有效的。我们发现，肌红蛋白重组的铁红三烯是一种梯形的血红素，表现出足够的氧气输送能力。

The development of artificial oxygen carrier is essential to support the stable blood transfusion. Artificial oxygen carrier is free from problem of blood type or blood infection, and it is preserved for longer period than blood itself. The blood substitutes so far developed are mainly from hemoglobin and related materials. Myoglobin has an advantage over hemoglobin because it is free from the influence of allosteric effector of solution pH. However, myoglobin has not been used as the blood substitute because of the extremely high oxygen affinity. We have developed a research to donate appropriate oxygen-transporting ability to myoglobin, and to utilize it as an efficient oxygen carrier. The rearrangement of the tetrapyrrole array in the porphyrin ring was quite effective to control the oxygen delivery. We found that the myoglobin reconstituted iron corrphycene, a trapezoidal heme, exhibits sufficient ability for oxygen delivery.