Creation of Artificial Oxygen Carrier Using Supramolecular Complex

人工氧载体的研制是维持稳定输血的必要条件。人工氧载体不存在血型或血液感染的问题，并且比血液本身保存时间更长。 目前已开发的血液代用品主要是血红蛋白及其相关物质。 肌红蛋白具有优于血红蛋白的优点，因为它不受溶液pH的变构效应的影响。然而，肌红蛋白由于极高的氧亲和力而未被用作血液替代品。 我们已经开展了一项研究，以捐赠适当的氧运输能力的肌红蛋白，并利用它作为一个有效的氧载体。四吡咯在卟啉环中的重排对控制氧的输送是相当有效的。 我们发现，肌红蛋白重构铁卟啉，梯形血红素，表现出足够的氧输送能力。

The development of artificial oxygen carrier is essential to support the stable blood transfusion. Artificial oxygen carrier is free from problem of blood type or blood infection, and it is preserved for longer period than blood itself. The blood substitutes so far developed are mainly from hemoglobin and related materials. Myoglobin has an advantage over hemoglobin because it is free from the influence of allosteric effector of solution pH. However, myoglobin has not been used as the blood substitute because of the extremely high oxygen affinity. We have developed a research to donate appropriate oxygen-transporting ability to myoglobin, and to utilize it as an efficient oxygen carrier. The rearrangement of the tetrapyrrole array in the porphyrin ring was quite effective to control the oxygen delivery. We found that the myoglobin reconstituted iron corrphycene, a trapezoidal heme, exhibits sufficient ability for oxygen delivery.