Creation of Artificial Oxygen Carrier Using Supramolecular Complex

研制人工氧载体是保障稳定输血的必要手段。人工氧载体不存在血型和血液感染的问题，而且比血液本身保存时间更长。目前开发的血液代用品主要来源于血红蛋白及相关物质。与血红蛋白相比，肌红蛋白的优势在于它不受溶液ph变构效应的影响。然而，由于其极高的氧亲和力，肌红蛋白尚未被用作血液替代品。我们开展了一项研究，为肌红蛋白提供适当的氧运输能力，并利用它作为有效的氧载体。卟啉环上的四吡咯排列重排对控制氧的传递是非常有效的。我们发现肌红蛋白重组铁卟酞，一种梯形血红素，表现出足够的氧气输送能力。

The development of artificial oxygen carrier is essential to support the stable blood transfusion. Artificial oxygen carrier is free from problem of blood type or blood infection, and it is preserved for longer period than blood itself. The blood substitutes so far developed are mainly from hemoglobin and related materials. Myoglobin has an advantage over hemoglobin because it is free from the influence of allosteric effector of solution pH. However, myoglobin has not been used as the blood substitute because of the extremely high oxygen affinity. We have developed a research to donate appropriate oxygen-transporting ability to myoglobin, and to utilize it as an efficient oxygen carrier. The rearrangement of the tetrapyrrole array in the porphyrin ring was quite effective to control the oxygen delivery. We found that the myoglobin reconstituted iron corrphycene, a trapezoidal heme, exhibits sufficient ability for oxygen delivery.