Development of SPECT probe for oxidative stress imaging

这些天，活体成像呈指数级增长，SPECT已成为临床应用中不可或缺的一部分。由于SPECT成像作为常规的临床诊断手段更具实用性，因此需要开发更好的SPECT成像探针。在本工作中，我们重点研究了用于体内氧化应激成像的SPECT探针的开发，以及生物氧化还原状态与与氧化应激相关的疾病如心血管疾病、缺血性疾病、糖尿病和癌症的关系。通常情况下，细胞或器官等生物系统中的还原剂和氧化剂的平衡维持在适当的状态，氧化还原状态的紊乱参与了这些疾病的发病或沉淀机制。因此，我们计划可视化氧化还原状态和ROS的产生水平。这些SPECT探针的临床应用将提供有关氧化应激的重要知识。

In vivo imaging have grown exponentially in these days, and SPECT has become indispensable in clinical use. Since SPECT imaging is more practical as routine clinical diagnostic procedures, the development of superior SPECT imaging probes had been required.In this work, we focused on the development of SPECT probes for imaging of in vivo oxidative stress, the relationships between biological redox state and diseases relevant to oxidative stress such as cardiovascular disease, ischemic disease, diabetes mellitus and cancer. Ordinarily, the balance of reductant and oxidant in biological systems such as cells or organs is maintained appropriate state, and disturbance of the redox state is involved in pathogenic or precipitating mechanism of these diseases. Therefore we planed to visualize the redox state and the production levels of ROS.The clinical application of these SPECT probes will provide significant knowledge on oxidative stress.