Efficient Skin Delivery of Polyphenols by Microemulsions and Its Mechanisms

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To deliver polyphenols such as resveratrol to skin, we prepared microemulsions using polyglycerin fatty acid esters and other surfactants, , which are known to be mild to skin. We examined the efficiency of intradermal delivery of polyphenols by in vitro study. The efficiencies of skin accumulation of polyphenols by the microemulsions using tetraglycerin mono-laurate or pentaglycerin mono-laurate as surfactant components were twice or three times more than those by microemulsions using Tween 80 as a surfactant component, which we had used. We also found different skin distribution of the polyphenols. Hydrophobic resveratrol with small molecular weight distributed to the dermis more than to the epidermis. On the other hand, hydrophilic chlorogenic acid with larger molecular weight distributed mostly to the epidermis. Therefore, polyphenols should be selected for purpose of skin application to skin.