Efficient Skin Delivery of Polyphenols by Microemulsions and Its Mechanisms

为了向皮肤输送白藜芦醇等多酚，我们使用聚甘油脂肪酸酯和其他表面活性剂制备了微乳液，这些表面活性剂对皮肤温和。我们通过体外研究检查了多酚的皮内递送效率。以单月桂酸四甘油酯或单月桂酸五甘油酯为表面活性剂成分的微乳剂在皮肤中积累多酚的效率是我们所使用的以吐温80为表面活性剂成分的微乳剂的两倍或三倍。我们还发现多酚在皮肤上的分布不同。小分子量的疏水性白藜芦醇分布在真皮中多于表皮。另一方面，分子量较大的亲水性绿原酸主要分布于表皮。因此，皮肤涂抹时应选择多酚类。

To deliver polyphenols such as resveratrol to skin, we prepared microemulsions using polyglycerin fatty acid esters and other surfactants, , which are known to be mild to skin. We examined the efficiency of intradermal delivery of polyphenols by in vitro study. The efficiencies of skin accumulation of polyphenols by the microemulsions using tetraglycerin mono-laurate or pentaglycerin mono-laurate as surfactant components were twice or three times more than those by microemulsions using Tween 80 as a surfactant component, which we had used. We also found different skin distribution of the polyphenols. Hydrophobic resveratrol with small molecular weight distributed to the dermis more than to the epidermis. On the other hand, hydrophilic chlorogenic acid with larger molecular weight distributed mostly to the epidermis. Therefore, polyphenols should be selected for purpose of skin application to skin.