Analysis of mechamisms in brain tumor stem cell regulation by polyphenol

多酚调控脑肿瘤干细胞的机制分析

• 批准号: 24700824
• 负责人: IKEGAME Yuka
• 金额: $ 2.83万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24700824/
• 关键词: ポリフェノール; 脳腫瘍幹細胞; レスベラトロール; 腫瘍抑制効果; 腫瘍幹細胞; 分化誘導

Resveratrol (RSV) is a natural polyphenolic compound, present in plants and food made from plants, that can cross the blood-brain barrier. Glioblastoma (GBM) is the most malignant primary brain tumor, which is known to have cancer stem cells (CSCs). CSCs appear to be an important cause of GBM's formidable resistance to various therapies, such as chemical agents or radiation.In the present study, RSV's anti-tumor effects against CSCs in GBM (U87 cells) and mechanisms including Sirtuin (SIRT) genes were indicated. The results from analyses of morphological changes and expressed proteins indicated: (1) RSV can induce GBM-CSC differentiation, which could make GBM more responsive to therapies; (2) RSV's anti-tumor effects on GBM may include mechanisms related to the activation or inactivation of SIRT genes (SIRT 1, 2, 3, 6) that induce CSC differentiation, which contribute to reduction of the malignancy, and cell death.

白藜芦醇（RSV）是一种天然多酚化合物，存在于植物和由植物制成的食品中，可以穿过血脑屏障。胶质母细胞瘤（GBM）是最恶性的原发性脑肿瘤，已知其具有癌症干细胞（CSC）。CSCs是导致GBM对化疗、放疗等治疗产生巨大抵抗力的重要原因之一，本研究主要探讨了RSV对GBM（U87细胞）CSCs的抗肿瘤作用及其机制，包括Sirtuin（SIRT）基因。形态学变化和表达蛋白的分析结果表明：（1）RSV可以诱导GBM-CSC分化，这可能使GBM对治疗更敏感;（2）RSV对GBM的抗肿瘤作用可能包括与SIRT基因（SIRT 1，2，3，6）激活或失活相关的机制，SIRT基因诱导CSC分化，这有助于降低恶性程度和细胞死亡。

项目成果

Among mesenchymal stem cells: for the best therapy after ischemic stroke.

• DOI: 10.1186/scrt157
• 发表时间: 2013-01-31
• 期刊: Stem cell research & therapy
• 影响因子: 7.5
• 作者: Ikegame Y

Among mesenchyma1 stem ce11s : for the best therapy after ischemic stroke

间充质1干细胞中：缺血性中风后的最佳治疗方法

• 发表时间: 2013
• 期刊: Stem Ce11 Research & Therapy
• 作者: Tsuruma K;Yamauchi M;Sugitani S;Otsuka T;Ohno Y;Nagahara Y;Ikegame Y;Shimazawa M;Yoshimura S;Iwama T;Hara H.;Ikegame Y
• 通讯作者: Ikegame Y