Analysis of mechamisms in brain tumor stem cell regulation by polyphenol

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Resveratrol (RSV) is a natural polyphenolic compound, present in plants and food made from plants, that can cross the blood-brain barrier. Glioblastoma (GBM) is the most malignant primary brain tumor, which is known to have cancer stem cells (CSCs). CSCs appear to be an important cause of GBM's formidable resistance to various therapies, such as chemical agents or radiation.In the present study, RSV's anti-tumor effects against CSCs in GBM (U87 cells) and mechanisms including Sirtuin (SIRT) genes were indicated. The results from analyses of morphological changes and expressed proteins indicated: (1) RSV can induce GBM-CSC differentiation, which could make GBM more responsive to therapies; (2) RSV's anti-tumor effects on GBM may include mechanisms related to the activation or inactivation of SIRT genes (SIRT 1, 2, 3, 6) that induce CSC differentiation, which contribute to reduction of the malignancy, and cell death.