The action of IL-24 involving the exacerbation of pneumonia in RSV-infected mice exposed perinatally to a brominated flame retardant.

点击翻译按钮获取中文摘要

To reveal effects of perinatal exposure to a brominated flame retardant TBBPA on the exacerbation of RSV-induced pneumonia, mechanism of action of IL-24 on RSV infection was investigated.By immune histopathological analysis, increase of the expression of IL-24 was confirmed in the lung tissues of RSV-infected mice exposed perinatally to TBBPA. The expression of IL-24 was also found in RA264.7 cells by real-time RT-PCR and western blotting in vitro. Although correlation between increase of IL-24 and decrease of a proinflammatory cytokine TNF-alpha was observed in the RSV-infected cells, direct interaction of them could not be revealed due to the failure of RNAi against IL-24 gene. Increase of IL-24 induced due to TBBPA-exposure might affect the production of proinflammatory cytokine from macrophages, should result in disorder of immune system responding to RSV infection.