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Electron microscopic analysis of lipid clusters and membrane proteins in plasma membrane.

Electron microscopic analysis of lipid clusters and membrane proteins in plasma membrane.
质膜中脂质簇和膜蛋白的电子显微镜分析。
批准号:
23590251
负责人:
MURATE Motohide
金额:
$3.41万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
We examined transbilayer and lateral lipid distribution in plasma membrane using recently developed peptide/proteins that selectively bind specific lipids or lipid clusters. The liposome experiments demonstrated that the lipids were effectively detected by the probes even when the membrane concentration was as low as 1 mol%, and the probes bound similarly to the model membranes that mimic outer or inner leaflet lipid environment.Next, we examined the distribution of sphingomyelin and phosphatidylserine in resting and thrombin-stimulated platelets as well as platelet microparticles that are highly procoagulant. Our results indicate that the scrambled membranes are selectively released in the form of microparticles in thrombin-activated platelets and suggest the idea that the exposure of phosphatidylserine in inner leaflet to the outer triggers the vesiculation of platelets.
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小林脂質生物学研究室
小林脂质生物实验室
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Transformation of phosphatidylethanolamine- and phosphatidylserine-containing membranes by phospholipase C beta 1
磷脂酶 C beta 1 转化含磷脂酰乙醇胺和磷脂酰丝氨酸的膜
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Tajima T, Inaba T, Kishimoto T, Abe M, Murate M, Makino A, Sakai S, Hullin-Matsuda F, Ishitsuka R, Ikeda Y, Takeoka S, Kobayashi T]
通讯作者: Kobayashi T
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Greimel P, Murate M, Hullin-Matsuda F, Nabetani T, Iwamoto K, Ito K, Takata M, Kobayashi M, Takahashi H, Kobayashi T]
通讯作者: Kobayashi T
Revisiting plasma membrane lipid asymmetry.
重新审视质膜脂质不对称性。
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Motohide Murate, Mitsuhiro Abe, Masato Umeda and Toshihide Kobayashi.]
通讯作者: Masato Umeda and Toshihide Kobayashi.
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