Paracellular permeability of tight junction examined by different combination of claudins or claudin-1 mutants.
Paracellular permeability of tight junction examined by different combination of claudins or claudin-1 mutants.
批准号:
20590193
负责人:
INAI Tetsuichiro
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We found by comparative analysis of mouse rectum CMT93-I and -II cells that expression of claudin-2 caused increase of paracellular permeability. This suggests that tight junction function may depend on combination of claudin species expressed in the cells. We found that two cysteine residues (54C, 64C) conserved in the first extracellular loop of claudin-1 were necessary for the formation of tight junction strands and that replacement of 54C to alanine caused increase of transepithelial electrical resistance.
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タイト結合の形態と機能
紧密连接的形式和功能
DOI:
--
发表时间:
2010
期刊:
福岡歯大誌 36巻、3号
影响因子:
--
作者:
[Zhu HL, Shibata A, Inai T, Nomura M, Shibata Y, Brock JA, Teramoto N, 稲井哲一朗, 稲井哲一朗]
通讯作者:
稲井哲一朗
DOI:
10.1002/ar.20683
发表时间:
2008-05-01
期刊:
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
影响因子:
2
作者:
[Inai, Tetsuichiro, Sengoku, Akihito, Shibata, Yosaburo]
通讯作者:
Shibata, Yosaburo
イントロンリテンションにより産出される新規接着分子Ceacam6-Lの精巣における発現と局在
Ceacam6-L(一种由内含子保留产生的新型粘附分子)在睾丸中的表达和定位
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[稲井哲一朗, ほか, 飯田弘ら]
通讯作者:
飯田弘ら
claudin-1の細胞外第二ループの変異によるタイト結合の形態の変化
由于claudin-1细胞外第二环的突变导致紧密连接形态的变化
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[稲井哲一朗, ほか]
通讯作者:
ほか
Characterization of Na_V1.6-mediated Na^+ currents in smooth muscle cells isolated from mouse vas deferens
从小鼠输精管分离的平滑肌细胞中 Na_V1.6 介导的 Na^ 电流的表征
DOI:
--
发表时间:
2010
期刊:
Journal of Cellular Physiology 233
影响因子:
--
作者:
[Zhu, et al.]
通讯作者:
et al.
共 27 条
Investigation of trans-interaction between claudins, tight junction constitutive transmembrane proteins, and paracellular permeability.
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批准号:23590249
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2011
-
负责人:INAI Tetsuichiro
-
依托单位:
Structural and functional analyses of E-face-associated tight junction strands formed by expression of claudin-1 mutant in the second extracellular loop in MDCKII cells
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批准号:18590187
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
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财政年份:2006
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负责人:INAI Tetsuichiro
-
依托单位:
Morphological and functional analysis of tight junction by overexpression or suppression of tight junction plaque protein ZO-1
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批准号:16590146
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:2004
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负责人:INAI Tetsuichiro
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依托单位:
海外基金