Targeting of mesenchymal stem cell associated with colorectal cancer liver metastasis

间充质干细胞靶向与结直肠癌肝转移相关

• 批准号: 23590430
• 负责人: OHMORI Hitoshi
• 金额: $ 3.16万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590430/
• 关键词: 骨髄間葉系幹細胞; 大腸癌; 肝転移; 脂肪酸; 癌幹細胞; カロリー制限; TGFβ; HMGB1; リノール酸; エライジン酸; がん幹細胞

Bone marrow-derived mesenchymal stem cell (MSC) enhances cancer progression and metastasis, which is one of cutting edges of cancer research. We reported that cancer cells-secreted HMGB1 employs MSC into tumors. Their stemness is retained by HMGB1 and TGF-beta-containing biglycan, which is cancer-derived extracellular matrix. This tissue status is often observed microscopically in diabetes-complicated colorectal cancer metastasizing to the liver. Absorbance or neutralization of HMGB1 inhibits employing MSC to suppress tumor growth and metastasis. These findings suggest that the targeting of MSC might be a promising method against cancer progression.

骨髓间充质干细胞（MSC）促进肿瘤的进展和转移，是肿瘤研究的前沿之一。我们报道了癌细胞分泌的HMGB 1利用MSC进入肿瘤。它们的干性由HMGB 1和含有TGF-β的双糖链蛋白聚糖（一种癌源性细胞外基质）保留。这种组织状态经常在显微镜下观察到糖尿病并发结直肠癌转移到肝脏。HMGB 1的吸收或中和抑制使用MSC来抑制肿瘤生长和转移。这些发现表明，MSC的靶向可能是一种有前途的抗癌症进展的方法。

项目成果

アンギオテンシン系および血糖調節を標的とする大腸癌肝転移の抑制

靶向血管紧张素系统和血糖调节抑制结直肠癌肝转移

• 发表时间: 2012
• 作者: 大森 斉;羅 奕;川田元清;千原良友;國安弘基
• 通讯作者: 國安弘基

AGE induce RAGE in the colonic mucosa of azoxymethane-injected Fischer 344 rats fed with a high-linoleic acid and high-glucose diet

AGE 在注射氧化偶氮甲烷并喂食高亚油酸和高葡萄糖饮食的 Fischer 344 大鼠的结肠粘膜中诱导 RAGE

• 发表时间: 2012
• 期刊: J Gastroenterol
• 影响因子: 6.3
• 作者: Shimomoto T;Ohmori H
• 通讯作者: Ohmori H

Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer

• DOI: 10.1002/ijc.27735
• 发表时间: 2013-02-15
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Shinagawa, Kei;Kitadai, Yasuhiko;Chayama, Kazuaki
• 通讯作者: Chayama, Kazuaki

Down-regulation of runt-related transcription factor 3 (RUNX3) associated with poor prognosis of adenoid cystic and mucoepidermoid carcinomas of the salivary gland

runt 相关转录因子 3 (RUNX3) 的下调与唾液腺腺样囊性癌和粘液表皮样癌的不良预后相关

• 发表时间: 2011
• 期刊: Cancer Science
• 影响因子: 5.7
• 作者: Sasahira T;Kurihara M;Yamamoto K;Bhawal UK (他2名)
• 通讯作者: Bhawal UK (他2名)

High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy

• DOI: 10.1016/j.ejca.2012.09.016
• 发表时间: 2013-02-01
• 期刊: EUROPEAN JOURNAL OF CANCER
• 影响因子: 8.4
• 作者: Luo, Yi;Chihara, Yoshitomo;Kuniyasu, Hiroki
• 通讯作者: Kuniyasu, Hiroki