The pathophysiology in hypoadiponectinemia

脂联素是一种由脂肪组织分泌到血液中的蛋白质，具有抗炎、抗糖尿病和抗动脉粥样硬化的功能。血浆脂联素水平降低与糖尿病等代谢综合征的组成部分密切相关。低脂联素和高浓度脂联素处理巨噬细胞系RAW264.7细胞48小时后，比较其基因表达情况，无显著差异，但炎症和免疫系统相关的许多基因表达水平存在差异。使用低脂联素浓度的基因工程小鼠，我们发现与野生型小鼠相比，巨噬细胞中抑制炎症的IL-10的表达减少了1/15，脂肪组织更容易发生炎症。我们正计划寻找药物来改善低脂联素浓度下这种容易发炎的情况。

Adiponectin is a protein which is secreted to blood from adipose tissue and has anti-inflammatory, anti-diabetes and anti-atherosclerosis functions. Decreased plasma adiponectin levels are well associated with components of the metabolic syndrome like diabetes.When macrophage cell line RAW264.7 cells were treated for 48 hours with low or high concentration of adiponectin and gene expressions were compared, there was no dramatic difference, but the expression level of many genes involved in inflammation and immune system were different. Using genetically engineered mice with low blood adiponectin concentration, we found that expression of IL-10 in macrophages, which suppresses the inflammation, decreased to 1/15 and the adipose tissue is prone to inflammation compared to wild type mice. We are planning to search medicines to ameliorate this easy-to-inflame condition under low adiponectin concentration.