Pathophysiological Roles of AdipoR1/AdipoR2 in the Prevention of Atherosclerosis

脂联素是一种重要的抗糖尿病和抗动脉粥样硬化的脂肪因子。然而，脂联素受体AdipoR 1和AdipoR 2在体内是否具有抗动脉粥样硬化的保护作用仍不确定。在这项研究中，我们使用常规的或组织特异性的AdipoR 1和/或AdipoR 2研究了AdipoR 1和AdipoR 2在动脉粥样硬化中的体内作用。或AdipoR 2基因敲除或转基因小鼠以及AdipoR基因敲除小鼠的骨髓移植。本研究提供了AdipoR 2基因敲除小鼠的直接证据，AdipoR 1和AdipoR 1对动脉粥样硬化具有保护作用。

The adipocyte-derived hormone adiponectin has been proposed to play the central roles as antidiabetic and antiatherogenic adipokine. However, whether adiponectin receptors AdipoR1 and AdipoR2 have the protective roles against atherosclerosis in vivo are still undetermined.Therefore, in this study we investigated the in vivo roles of AdipoR1 and AdipoR2 on atherosclerosis using conventional or tissue-specific AdipoR1 and/or AdipoR2 knockout or transgenic mice as well as transplantation of bone marrow from AdipoR knockout mice.This study provides the direct evidence that AdipoR2 in endothelial cells and AdipoR1 in macrophages play protective roles against atherosclerosis in vivo.