Mechanisms of suppressed recall responses of CD8+T cells during malaria infection

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FTY720, which inhibits lymphocyte emigration from lymphoid organs, did not affect against the reduced expansion of memory OT-I cells compared with naive OT-I cells during OVA malaria infection, suggesting that the recall response was reduced systemically during malaria infection.Immunohistochemistory indicated that OT-I cells and macrophages did not accumulate in white pulp of spleen so much during OVA malaria infection. This result suggested that the location of antigen presentation may be important for cell expansion.Immunization of OVA-pulsed BMDC did not induced the difference in the ratio of naive OT-I cells and memory OT-I cells during the infections between wild type malaria and listeria, implying the possibility that the reduced recall response might be dependent on antigen presentation.