Ophthalmologic assessment of retinal vessels as a biomarker of the pharmacological response to antiangiogenic cancer chemotherapy

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To explore biomarkers of the pharmacological response to cancer chemotherapy including angiogenic inhibitors, this research assessed ophthalmologic findings of retinal vessels of total 137 patients who receiving cancer chemotherapy. The retinal vessel diameters; were more likely to shrink in those who responded to the preoperative treatment of colorectal cancer; clearly reflected therapeutic efficacy in those with refractory multiple myeloma; and showed a marked reduction in those who obtained long-term stable disease during the treatment of metastatic colorectal cancer.