Molecular characterization of IPMN using comprehensive genome analysis

使用综合基因组分析对 IPMN 进行分子表征

• 批准号: 23591010
• 负责人: TADA Minoru
• 金额: $ 3.33万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591010/
• 关键词: IPMN

We characterized the molecular signature of IPMN in this project. 11 gastric, 11 intestinal, one pancreatobiliary, and two oncocytic types were included in this study. We compared the molecular characteristics of two major subtypes, gastric-type and intestinal-type IPMN. Gastric-type showed a higher incidence of KRAS mutations (9/11, 81.8%) compared with intestinal type (3/11, 27.3%). The intestinal type (9/11, 81.8%) demonstrated more frequent SMAD1/5/8 phosphorylation compared with gastric-type IPMN (3/11, 27.3%).In addition, we identified a molecule that accerelated epithelial- mesenchymal transition in pancreas cancer cells. The gene was amplified in pancreas cancer cells and human pancreatic tumors. We now examine the significance of the molecule in IPMN as well as in pancreatic cancers.

在本项目中，我们表征了IPMN的分子特征。本研究包括11例胃、11例肠、1例胰胆和2例嗜酸细胞类型。我们比较了两种主要亚型，胃型和尿道型IPMN的分子特征。胃型KRAS突变发生率（9/11，81.8%）高于肠型（3/11，27.3%）。肠型胰腺癌细胞（9/11，81.8%）的SMAD1/5/8磷酸化频率高于胃型胰腺癌细胞（3/11，27.3%）。该基因在胰腺癌细胞和人胰腺肿瘤中扩增。我们现在研究的重要性，分子在IPMN以及胰腺癌。

项目成果

A novel, fully covered laser-cut nitinol stent with antimigration properties for nonresectable distal malignant biliary obstruction: a multicenter feasibility study.

• DOI: 10.5009/gnl.2013.7.6.725
• 发表时间: 2013-11
• 期刊: Gut and liver
• 影响因子: 3.4
• 作者: Isayama H;Kawakubo K;Nakai Y;Inoue K;Gon C;Matsubara S;Kogure H;Ito Y;Tsujino T;Mizuno S;Hamada T;Uchino R;Miyabayashi K;Yamamoto K;Sasaki T;Yamamoto N;Hirano K;Sasahira N;Tada M;Koike K
• 通讯作者: Koike K

Prognostic factors in patients with advanced biliary tract cancer receiving chemotherapy

• DOI: 10.1007/s00280-010-1360-7
• 发表时间: 2011-04-01
• 期刊: CANCER CHEMOTHERAPY AND PHARMACOLOGY
• 影响因子: 3
• 作者: Sasaki, Takashi;Isayama, Hiroyuki;Koike, Kazuhiko
• 通讯作者: Koike, Kazuhiko

A multicentre randomised phase II trial of gemcitabine alone vs gemcitabine and S-1 combination therapy in advanced pancreatic cancer: GEMSAP study.

• DOI: 10.1038/bjc.2012.183
• 发表时间: 2012-06-05
• 期刊: British journal of cancer
• 影响因子: 8.8
• 作者: Nakai Y;Isayama H;Sasaki T;Sasahira N;Tsujino T;Toda N;Kogure H;Matsubara S;Ito Y;Togawa O;Arizumi T;Hirano K;Tada M;Omata M;Koike K
• 通讯作者: Koike K

The results of the Tokyo trial of prevention of post-ERCP pancreatitis with risperidone (Tokyo P3R): a multicenter, randomized, phase II, non-placebo-controlled trial

使用利培酮预防 ERCP 后胰腺炎的东京试验 (Tokyo P3R) 的结果：一项多中心、随机、II 期、非安慰剂对照试验

• 发表时间: 2013
• 期刊: J Gastroenterol
• 影响因子: 6.3
• 作者: Tsujino T;Isayama H;Nakai Y;Ito Y;Togawa O;Toda N;Arizumi T;Kogure H;Yamamoto K;Mizuno S;Yashima Y;Yagioka H;Sasaki T;Matsubara S;Yamamoto N;Hirano K;Sasahira N;Tada M;Koike K
• 通讯作者: Koike K

ENDOSCOPIC REMOVAL OF A SPONTANEOUSLY FRACTURED BILIARY UNCOVERED SELF‐EXPANDABLE METAL STENT

内镜下切除自发断裂的胆管未覆盖的自膨胀金属支架

• DOI: 10.1111/j.1443-1661.2011.01189.x
• 发表时间: 2012
• 期刊: Digestive Endoscopy
• 影响因子: 5.3
• 作者: K. Kawakubo;H. Isayama;T. Tsujino;Y. Nakai;N. Sasahira;H. Kogure;T. Hamada;R. Nagano;K. Miyabayashi;Keisuke Yamamoto;D. Mohri;Takashi Sasaki;Yukiko Ito;N. Yamamoto;K. Hirano;M. Tada;K. Koike
• 通讯作者: K. Koike