使用综合基因组分析对 IPMN 进行分子表征-猫眼课题宝

使用综合基因组分析对 IPMN 进行分子表征

批准号：

23591010

负责人：

TADA Minoru

金额：

$3.33万

依托单位：

The University of Tokyo

依托单位国家：

日本

项目类别：

Grant-in-Aid for Scientific Research (C)

财政年份：

2011

资助国家：

日本

项目状态：

已结题

起止时间：

2011 至 2013

来源：

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591010/

关键词：

IPMN

项目摘要

项目成果

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中文摘要

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英文摘要

We characterized the molecular signature of IPMN in this project. 11 gastric, 11 intestinal, one pancreatobiliary, and two oncocytic types were included in this study. We compared the molecular characteristics of two major subtypes, gastric-type and intestinal-type IPMN. Gastric-type showed a higher incidence of KRAS mutations (9/11, 81.8%) compared with intestinal type (3/11, 27.3%). The intestinal type (9/11, 81.8%) demonstrated more frequent SMAD1/5/8 phosphorylation compared with gastric-type IPMN (3/11, 27.3%).In addition, we identified a molecule that accerelated epithelial- mesenchymal transition in pancreas cancer cells. The gene was amplified in pancreas cancer cells and human pancreatic tumors. We now examine the significance of the molecule in IPMN as well as in pancreatic cancers.

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会议论文

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DOI： 10.5009/gnl.2013.7.6.725

发表时间： 2013-11

期刊：

Gut and liver

影响因子： 3.4

作者：

[Isayama H, Kawakubo K, Nakai Y, Inoue K, Gon C, Matsubara S, Kogure H, Ito Y, Tsujino T, Mizuno S, Hamada T, Uchino R, Miyabayashi K, Yamamoto K, Sasaki T, Yamamoto N, Hirano K, Sasahira N, Tada M, Koike K]

通讯作者： Koike K

Prognostic factors in patients with advanced biliary tract cancer receiving chemotherapy

DOI： 10.1007/s00280-010-1360-7

发表时间： 2011-04-01

期刊：

CANCER CHEMOTHERAPY AND PHARMACOLOGY

影响因子： 3

作者：

[Sasaki, Takashi, Isayama, Hiroyuki, Koike, Kazuhiko]

通讯作者： Koike, Kazuhiko

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DOI： 10.1038/bjc.2012.183

发表时间： 2012-06-05

期刊：

British journal of cancer

影响因子： 8.8

作者：

[Nakai Y, Isayama H, Sasaki T, Sasahira N, Tsujino T, Toda N, Kogure H, Matsubara S, Ito Y, Togawa O, Arizumi T, Hirano K, Tada M, Omata M, Koike K]

通讯作者： Koike K

The results of the Tokyo trial of prevention of post-ERCP pancreatitis with risperidone (Tokyo P3R): a multicenter, randomized, phase II, non-placebo-controlled trial

使用利培酮预防 ERCP 后胰腺炎的东京试验 (Tokyo P3R) 的结果：一项多中心、随机、II 期、非安慰剂对照试验

DOI： --

发表时间： 2013

期刊：

J Gastroenterol

影响因子： 6.3

作者：

[Tsujino T, Isayama H, Nakai Y, Ito Y, Togawa O, Toda N, Arizumi T, Kogure H, Yamamoto K, Mizuno S, Yashima Y, Yagioka H, Sasaki T, Matsubara S, Yamamoto N, Hirano K, Sasahira N, Tada M, Koike K]

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ENDOSCOPIC REMOVAL OF A SPONTANEOUSLY FRACTURED BILIARY UNCOVERED SELF‐EXPANDABLE METAL STENT

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发表时间： 2012

期刊：

Digestive Endoscopy

影响因子： 5.3

作者：

[K. Kawakubo, H. Isayama, T. Tsujino, Y. Nakai, N. Sasahira, H. Kogure, T. Hamada, R. Nagano, K. Miyabayashi, Keisuke Yamamoto, D. Mohri, Takashi Sasaki, Yukiko Ito, N. Yamamoto, K. Hirano, M. Tada, K. Koike]

通讯作者： K. Koike