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Molecular Mechanisms of Hyper-contraction of Drug-eluting Stent Implanted Coronary Arteries

Molecular Mechanisms of Hyper-contraction of Drug-eluting Stent Implanted Coronary Arteries
药物洗脱支架植入冠状动脉超收缩的分子机制
批准号:
20590875
负责人:
YASUDA Satoshi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Accumulating evidence indicates that coronary vasoconstricting responses are enhanced at the edges of coronary segment implanted with drug-eluting stents (DES) compared with bare-metal stent (BMS) in humans. We have recently demonstrated that Rho-kinase pathway plays an important role in DES-induced coronary hyperconstricting responses in pigs in vivo and in patients with coronary artery diseases. Also, chronic treatment with long-acting nifedipine suppresses DES-induced coronary hyperconstricting responses and inflammatory changes, at least in part, through Rho-kinase pathway inhibition in pigs in vivo.
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Long-term treatment with eicosapentaenoic acid ameliorates myocardial ischemia-reperfusion injury in pigs in vivo -A potential role of Rho-kinase pathway-.
二十碳五烯酸长期治疗可改善猪体内心肌缺血再灌注损伤 - Rho 激酶途径的潜在作用 -。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Gao JY, Yasuda S, Tsuburaya R, Ito Y, Aizawa K, Kikuchi Y, Ito K, Shimokawa H.]
通讯作者: Shimokawa H.
冠攣縮性狭心症診療の現状と問題点
血管痉挛性心绞痛治疗现状及问题
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [安田聡, 小川久雄, 下川宏明]
通讯作者: 下川宏明
Rho-kinase Pathway Plays an Important Role in the Pathogenesis of Coronary Hyperconstricting Responses Induced by Drug-Eluting Stent
Rho激酶通路在药物洗脱支架引起的冠状动脉过度收缩反应的发病机制中发挥重要作用
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Shiroto T, Yasuda S, et.al.]
通讯作者: et.al.
循環器疾患のサイエンス.東京(冠攣縮性狭心症)(小室一成編)
东京心血管疾病科学(Vanary痉挛性心绞痛)(小室一成编辑)
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [安田聡, 下川宏明]
通讯作者: 下川宏明
21
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    • 批准号:
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    • 项目类别:
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    • 资助金额:
      $2.83万
    • 财政年份:
      2011
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    • 财政年份:
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    • 资助金额:
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    • 财政年份:
      2009
    • 负责人:
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    • 依托单位:
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