the impact of epicardial adipose tissue on the development of atherosclerotic coronary artery disease

我们研究了多探头CT测量的心外膜脂肪组织（EAT）体积和心包液中脂联素水平对肥胖和非肥胖患者冠心病发展的影响。与非CAD患者相比，CAD患者的EAT体积明显更高。伴有和不伴有CAD的肥胖患者的EAT量无显著差异。非肥胖冠心病患者的EAT明显高于非肥胖冠心病患者（35.0 + 18.8 mL vs. 16.9 + 10.5 mL, p < 0.01）。非肥胖冠心病患者心包液中脂联素浓度明显低于非肥胖冠心病患者。多元logistic回归分析显示，非肥胖患者的EAT体积增加与冠心病的进展独立相关。在非肥胖患者中，EAT可能与冠心病的发展有关。脂联素分泌减少可能与冠状动脉粥样硬化的发生有关。

We investigated the impact of epicardial adipose tissue(EAT) volume measured by multi-detector CT and adiponectin level in pericardial fluid on the development of CAD in obese and non-obese patients. EAT volume was significantly higher in CAD patients compared to non CAD patients. EAT volume was not significantly different between obese patients with and without CAD. EAT was significantly higher in non-obese patients with CAD compared to those without CAD (35.0 + 18.8 mL vs. 16.9 + 10.5 mL, p < 0.01). Adiponectin concentration in pericardial fluid was significantly lower in non-obese patients with CAD compared to those without CAD. Multiple logistic regression analysis showed that increment of EAT volume correlated independently with the progression of CAD in non-obese patients.EAT may be associated with the development of CAD in non-obese patients. The decreased secretion of adiponectin from EAT may contribute to the development of coronary atherosclerosis.