Effects of remote ischemic conditioning on coronary endothelial vasomotor function in patients treated with drug eluting stents

远程缺血调理对药物洗脱支架患者冠状动脉内皮血管舒缩功能的影响

• 批准号: 23591034
• 负责人: NAKAMURA Takamitsu
• 金额: $ 3万
• 依托单位: University of Yamanashi
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591034/
• 关键词: Remote conditioning; DES; 内皮機能; 血管内皮機能

In this study, we investigated the effects of remote ischemic conditioning in acute coronary syndrome (ACS) patients treated with drug-eluting stents (DES). Fifty ACS patients were randomly assigned to receive remote ischemic conditioning (remotecon) or as control before DES implantation. All patients were followed up for <2 years or until the occurrences of coronary events including cardiac death, non-fatal myocardial infarction, and unstable angina requiring revascularization therapy. During follow up periods, 9 coronary events were observed. However, there were no significant differences in occurrence of coronary events between 2 groups (4patients [16%], in remote con, vs. 5 patients [20%], in control, p = 0.48). Moreover, assessment of vasomotor function in the infarct-related artery at 14 days in a subgroup of 30 patients showed that there was a trend in preservation of endothelial vasomotor function in remotecon group compared with control.

在这项研究中，我们研究了远程缺血预处理在急性冠脉综合征（ACS）患者中的作用，这些患者接受了药物洗脱支架（DES）治疗。50例ACS患者在DES植入前被随机分配接受远程缺血预处理（remotecon）或作为对照。所有患者随访<2年或直至发生冠状动脉事件，包括心源性死亡、非致命性心肌梗死和需要血运重建治疗的不稳定型心绞痛。 在随访期间，观察到9例冠状动脉事件。然而，两组之间的冠状动脉事件发生率无显著差异（4例患者[16%]，远程控制组vs. 5例患者[20%]，对照组，p = 0.48）。此外，在30例患者的一个亚组中，在14天时对梗死相关动脉的血管功能进行评估，结果表明，与对照组相比，remotecon组的内皮血管功能有保留的趋势。

项目成果

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