Effects of remote ischemic conditioning on coronary endothelial vasomotor function in patients treated with drug eluting stents

在这项研究中，我们研究了药物洗脱支架（DES）治疗的急性冠脉综合征（ACS）患者的远端缺血适应的影响。50例ACS患者在DES植入前随机分为远程缺血调节组（remotecon）和对照组。所有患者随访时间均小于2年，或直到发生冠状动脉事件，包括心源性死亡、非致死性心肌梗死和需要血运重建治疗的不稳定型心绞痛。在随访期间，观察到9例冠状动脉事件。然而，两组之间冠状动脉事件的发生率无显著差异（远程对照组4例[16%]，对照组5例[20%]，p = 0.48）。此外，对30例患者的亚组中14天梗死相关动脉血管舒缩功能的评估显示，与对照组相比，remotecon组内皮血管舒缩功能有保存的趋势。

In this study, we investigated the effects of remote ischemic conditioning in acute coronary syndrome (ACS) patients treated with drug-eluting stents (DES). Fifty ACS patients were randomly assigned to receive remote ischemic conditioning (remotecon) or as control before DES implantation. All patients were followed up for <2 years or until the occurrences of coronary events including cardiac death, non-fatal myocardial infarction, and unstable angina requiring revascularization therapy. During follow up periods, 9 coronary events were observed. However, there were no significant differences in occurrence of coronary events between 2 groups (4patients [16%], in remote con, vs. 5 patients [20%], in control, p = 0.48). Moreover, assessment of vasomotor function in the infarct-related artery at 14 days in a subgroup of 30 patients showed that there was a trend in preservation of endothelial vasomotor function in remotecon group compared with control.