Significance of Lp(a) cholesterol in the risk determination of atherosclerosis

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HPLC lipoprotein analysis showed that in 212 male subjects without cardiovascular disease Lp(a)-C did not correlate with LDL-C while Lp(a)-C correlated positively with IDL-C, VLDL-C, chylomicron-C, but inversely correlated with HDL-C. Framingham Risk Score for atherosclerosis significantly provided a positive correlation to non-HDL-C but a modest correlation to Lp(a)-C. In the basic experiments to establish the study for Lp(a) effects on secretion of MMP-2, a destabilizing factor of atherosclerosis, from vascular endothelial cells, angiotensin 2 (Ang2) enhanced MMP-2, and the Ang2 receptor blocker cancelled that, and thereby it was found that Ang2 could enhance MMP-2 through Ang2 receptors. Although Lp(a) also may have certain potential to enhance MMP-2, its reproducibility and its mechanisms should be revealed. Therefore, Lp(a)-C and MMP-2 may be expected to play a role in biomarkers of cardiovascular disease.