Developmental reserch of the novel therapy for intractable pulmonary diseases such as pulmonary fibrosis

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Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor of mesothelial origin that shows a limited response to conventional chemotherapy and radiotherapy. Therefore, diagnosing MPM early is very important. We demonstrated that patients with MPM had significantly higher serum levels of some markers such as HMGB1, thioredoxin, angiopoietin-1 than the population who had been exposed to asbestos but had not developed MPM. The difference in overall survival between groups with serum HMGB1 and angiopoietin-1 levels that were lower and higher than assumed cut-off values was significant.Our data suggest that serum HMGB1, thioredoxin and angiopoietin-1 concentrations are useful clinical markers for MPM.