Involvement of mitochondrial ROS in the pathogenesis of diabetic complications

我们先前报道，高血糖诱导的线粒体活性氧物种(ROS)是糖尿病并发症发病机制中的关键事件。本研究探讨低氧诱导因子-1-α(HIF-1α)在糖尿病并发症发病机制中的作用，阐明高血糖可通过高血糖诱导的线粒体ROS和高血糖诱导的细胞内低氧相互作用而促进糖尿病并发症的发生。

We previously reported that hyperglycemia-induced mitochondrial reactive oxygen species (ROS) is the key event in the pathogenesis of diabetic complications. In this study, we examined the role of hypoxia-inducible factor-1-alpha (HIF-1alpha) induction in the pathogenesis of diabetic complications, and we clarify that hyperglycemia can progress diabetic complications by the interaction between hyperglycemia-induced mitochondrial ROS and hyperglycemia-induced intracellular hypoxia.