High-density lipoprotein composition and development of coronary artery disease

许多研究表明，高密度脂蛋白(高密度脂蛋白)的组成可能有助于冠状动脉粥样硬化的发展，而不是高密度脂蛋白-胆固醇。在这项研究中，我们证明了高密度脂蛋白-甘油三酯/高密度脂蛋白比值升高与许多心血管危险因素显著相关。该指标与糖尿病和慢性肾脏疾病密切相关，可能代表高密度脂蛋白的功能异常。血浆胆固醇酯转运蛋白(CETP)质量与高密度脂蛋白-甘油三酯/高密度脂蛋白比值呈正相关。日本常见遗传背景的CETP缺乏症患者的高密度脂蛋白-甘油三酯/高密度脂蛋白比值显著降低。

Many studies suggest that high-density lipoprotein (HDL) composition may contribute to coronary atherosclerosis development rather than HDL-cholesterol. In this study, we demonstrated that increased HDL-TG/HDL-PL ratio was significantly associated with many cardiovascular risk factors. This index was strongly correlated with diabetes and chronic kidney disease, and may represent functional abnormalities of HDL.Plasma cholesteryl-ester transfer protein (CETP) mass showed positive correlation with HDL-TG/HDL-PL ratio. HDL-TG/HDL-PL ratio was significantly lower in CETP deficiency, common genetic background in Japan.