A study on inducible oxidative protein by hyperbaric oxygen exposure.

已有大量关于诱导应激蛋白的活性与各种药物联合使用以对抗活性氧的研究。然而，诱导应激蛋白尚未应用于临床。本研究的目的是通过抑制氧化蛋白的表达来保护主要器官。通过检测肾脏和肝脏中血红素加氧酶-1阳性细胞的数量来检测氧化蛋白的表达。在内毒素+高压氧暴露组，肾脏和肝脏中有大量的血红素加氧酶-1阳性细胞，提示高压氧暴露可以诱导氧化蛋白的表达。人们希望高压氧暴露将有助于可预见的严重发病率。需要进一步的研究才能更准确地识别候选蛋白质。

There have been numerous studies of the activity of the inducible stress protein in combination with various drugs against inhibition of reactive oxygen species. However, the inducible stress proteins have not been yet applied clinically. The purpose of this study was to protect of major organs by constraint expression of oxidative protein.We examined expression of oxidative proteins by measuring the number of heme oxygenase-1 positive cell in the kidney and liver.Many positive heme oxygenase-1 cell were shown in kidney and liver in LPS plus hyperbaric oxygen exposure group.The results suggested that hyperbaric oxygen exposure can induce oxidative proteins. It is hoped that hyperbaric oxygen exposure will help in predictable serious morbidity. Further studies are needed to more accurately identify candidate proteins.